PhD Student (M/F) - Engineering a skeletal muscle-on-a-chip
New
- FTC PhD student / Offer for thesis
- 36 month
- BAC+5
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Laboratoire interdisciplinaire de physique
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
38402 ST MARTIN D HERES
Contract Duration
36 month
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 26 June 2026 23:59
Job Description
Thesis Subject
Skeletal muscle plays essential roles in locomotion, respiration, thermoregulation, and metabolic homeostasis. Its integrity is critically compromised in a wide range of conditions such as myopathies or age-related sarcopenia and chronic diseases including cancer and diabetes. Despite major progress in disease modeling and regenerative therapies, current in vitro models of human skeletal muscle fail to reproduce the physiological complexity of native muscle tissue, particularly its spatial organization, cellular complexity and domain-specific functionality.
Our team already demonstrated the feasibility and performance of engineered 3D muscle tissues. The PhD aims to engineer a next-generation muscle-on-a-chip platform that replicates not only the structural and contractile features of muscle fibers, but also integrates the two critical anatomical and functional interfaces: neuromuscular junctions and myotendinous junctions. To this end, the PhD student will be in charge of the design, fabrication, optimization and characterization of the platform. Design will be created using CAD software and fabricated using stereolithographic 3D-printing of resin. The geometric and mechanical properties of the platform will be assessed using optical microscopy and a micromechanical testing system. Biological compatibility will be first evaluated in LIPhy using immortalized cell lines before assessing the formation and maturation of muscle tissues with our collaborator N. Didier (IMRB Créteil).
This PHD will provide a highly interdisciplinary training to the student, who will acquire skills in different aspects of bioengineering: : he/she will learn and practice cell culture, CAD, stereolithographic 3D printing, soft replication, micromechanical testing, immunostaining, fluorescence microscopy and image analysis (ImageJ, Python). He/she will also acquire valuable skills in long-term project management, teamwork, and scientific communication. Communications within the lab will be in English.
Your Work Environment
The student will primarily work at LIPhy in Grenoble, with some assignments at the laboratory of Dr. N. Didier in Créteil.
The PhD will be conducted within the MicroTiss team (https://liphy.univ-grenoble-alpes.fr/fr/recherche/equipes/microtiss)
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR5588-THOBOU-002 |
|---|---|
| CN Section(s) / Research Area | Pharmacology, bio-engineering, imaging, biotechnology |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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