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Thesis proposal (H/F) "Study of the dynamics of cell adhesive structure in 3D environment

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Français - Anglais

Date Limite Candidature : vendredi 23 octobre 2020

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General information

Reference : UMR5309-CORALB0-001
Workplace : LA TRONCHE,LA TRONCHE
Date of publication : Friday, October 02, 2020
Scientific Responsible name : Corinne Albiges-Rizo
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 November 2020
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

Adhesive membrane receptors sense extracellular signals and mechanically transmit intracellular signals to coordinate cell shape, cell migration and cell identity. These receptors are often localized in specific regions, as in the case of microdomains enriched with adhesive receptors and co-receptors; however, the dynamic interactions of the receptors with various co-receptors within microdomains on cell surfaces remain largely unexplored. The aim of the thesis will be to understand the dynamics of adhesive receptors and co-receptors in complex biomimetic environments in order to identify the impact of these dynamics on cell identity.

Work Context

The work will be carried out in our group "Dynamics of Cell Afesion and Differentiation" at the Institute for Advanced Biosciences, La Tronche. The team has a long experience in adhesive systems research covering a wide range of approaches to study the impact of the dynamics of adhesion structures on cell migration, invasion and identity. The group is composed of 4 permanent scientists, 2 Assistant Engineers, 1 technician, and 1 PhD student.

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