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PhD student (M/F) on intestinal stem cells/cancer stem cells

This offer is available in the following languages:
Français - Anglais

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General information

Reference : UMR5286-MICPLA-001
Workplace : LYON 08
Date of publication : Monday, January 28, 2019
Scientific Responsible name : Dr Michelina PLATEROTI
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 April 2019
Proportion of work : Full time
Remuneration : 1 768,55 € gross monthly

Description of the thesis topic

Missions:
The PhD student (M/F) will be part of the Team Development, cancer and stem cells leaded by Dr Michelina Plateroti. The selected candidate will contribute to the studies of intestinal physiopathology with a specific focus on stem cell biology in both normal and cancer context. In particular, signalling networks maintaining stem cell homeostasis will be studied and the effects of their alterations on stem cell transformation and cancer development analysed in detail. He/she will work under the supervision of Dr Plateroti and in collaboration with other team members within the framework of the programme funded by the Fondation pour la Recherche Medicale (Equipe labellisée FRM).

Activities:
The PhD student will be in charge of developing the above project. He/she is expected to learn and become independent in planning, performing and interpreting the experiments. He/she will also work with mouse models and will be trained to the French/European good practices in animal experimentation. In addition, he/she will master the literature associated with the project and be able to communicate his/her results in the lab and outside.

Skills:
The applicant must hold a Master 2 (or equivalent) diploma in Biology or in Health sciences. He/she is expected to have experience in the field of molecular and cellular biology and a good knowledge of cancer biology. Previous experience with animals, cell culture (primary or cell lines) and/or manipulating gene expression will be a plus. The candidate must have a positive attitude as a team member and should be able to communicate (oral and written skills) in English.

Work Context

The Team Development, cancer and stem cells is part of the Cancer Cell Plasticity department of the Cancer Research Centre of Lyon (CRCL - INSERM U1052 / CNRS 5286). The candidate will benefit from the international scientific environment (24 teams and about 450 people dedicated to cancer research) and the technical platforms provided by the research center. The CRCL is affiliated to CNRS and INSERM French research agencies, to the University Claude Bernard Lyon 1 and to the Oncology Hospital "Centre Léon Bérard".

Constraints and risks

Work with human cells and with engineered mice.

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