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PhD student (H/F)

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : mardi 11 octobre 2022

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General information

Reference : UMR5286-ERICOS-003
Workplace : LYON 08
Date of publication : Tuesday, September 20, 2022
Scientific Responsible name : Erika COSSET
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 January 2023
Proportion of work : Full time
Remuneration : 2135€ gross monthly

Description of the thesis topic

To survive the various stresses present in the micro-environment (such as nutrient and oxygen deprivation, and the presence of anticancer treatments), tumor cells develop several mechanisms, whose macropinocytosis, an endocytosis process, allowing them to absorb large amounts of nutrients from the local microenvironment. We have demonstrated the involvement of Galectin-3 in the induction of macropinocytosis in the mesenchymal cells of Glioblastoma (brain tumors of poor prognosis). Our results showed that the induction of macropinocytosis is not restricted to tumors carrying specific mutations in oncogenes (such as KRAS), but potentially induced as a result of environmental stress. In this context, the main objective of this study is to identify the molecular mechanisms of cancer cells dependence on macropinocytosis, with the ultimate goal of identifying druggable targets. To achieve this goal, various functional, metabolomic, transcriptomic and proteomic analyses will be combined with a laser microdissection capture technique combined with mass spectrometry.

Work Context

The CRCL (UMR Inserm 1052 – CNRS 5286 – Centre Léon Bérard) is a cancer research structure certified by the University of Lyon 1, Inserm, the CNRS, the Centre Léon Bérard and with the Hospices Civils de Lyon as hospital partner.
The host laboratory is located within the CRCL and benefits from many platforms. The host team certified by the ATIP-Avenir and ERC Starting Grant programs offers an environment conducive to this thesis.

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