PhD student in biomolecular simulations (M/F)

Job Description

Thesis Subject

Myosins are molecular motors involved in several critical cellular processes. They convert the free energy released from ATP hydrolysis into mechanical work on actin filaments, thanks to allosteric communication between the active site and the force-generating subdomains. In muscle cells, myosins assemble within large structures called sarcomeres, where they play a central role in muscle contraction. One of the functional regulation mechanisms of the sarcomere relies on the incorporation of different myosin isoforms. In particular, myosin 18 emerges as a key regulator of muscle myosin 2 and is involved in various pathologies. Surprisingly, myosin 18 has lost its ability to hydrolyze ATP and, consequently, to function as a molecular motor. Furthermore, it exhibits unique disordered extensions within the myosin superfamily.

We propose a PhD project aimed at understanding, at the atomic scale, how the unique features of myosin 18 enable it to fulfill its regulatory role, using modeling and simulation approaches. Various computational methods will be employed to investigate the structural and dynamic properties of this protein, as well as its interactions with other cellular components. The obtained results will be compared with available experimental data, in collaboration with our partners.

We are seeking a candidate holding a Master 2 degree in computational biophysics, structural bioinformatics, or a related field. Knowledge of statistical mechanics and/or machine learning would be an asset. The ideal candidate will demonstrate scientific curiosity, motivation for fundamental research, and the ability to work in a team within an interdisciplinary environment. We strongly encourage applications from individuals belonging to underrepresented or disadvantaged groups, in line with our commitment to diversity and inclusion. The funding duration is three years, with a planned start in October 2026.

Your Work Environment

The PhD student will work within the Biophysics of Complex Systems team at the Institut des Sciences Analytiques (ISA), located in Villeurbanne on the campus of Université Claude Bernard Lyon 1. ISA is a research laboratory in analytical chemistry, biophysics, biochemistry, and molecular modeling, developing experimental and numerical approaches for the study of complex molecular systems. Within this institute, the Biophysics of Complex Systems team focuses on the structural and dynamic characterization of intrinsically disordered and multidomain proteins involved in major biological processes, combining experimental biophysics approaches (SAXS, NMR, crystallography) and molecular simulations. The PhD student is recruited within the ANR-funded project MyoAssemble.

Compensation and benefits

Compensation

2300 € gross monthly

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

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