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Development of hybrid organic-inorganic solids for enhancing nmr signals by dnp (H/F)

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Français - Anglais

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General information

Reference : UMR5265-CHLTHI-002
Workplace : VILLEURBANNE
Date of publication : Thursday, August 08, 2019
Scientific Responsible name : Chloé Thieuleux
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2019
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

The aim of this project is the development of innovative porous silica-based materials containing organic stable radicals (TEMPO units) using sol-gel techniques. This project will be performed in the frame of o collaboration between the C2P2 laboratory and the CRMN in Lyon. This project already led to very promising results published in high ranked journals (PNAS, ACIE, Nature Communications, Chem. Sci.).
The first generation of silica matrices allowed to yield pure solutions of 'hyperpolarized' tracers that are promising as contrast agents for in-vivo MRI experiments such as the real-time in-vivo detection of cancer tumours. Using this technique, cancerous regions that were invisible to standard MRI techniques could be identified without ionizing radiations and without any false positives.
To reach this goal, new silica matrices need to be developed to ensure long live hyperpolarization state of the tracers as so far hyperpolarized samples are only very short lived (typically 1 minute) which prevents their widespread use.


In this context, we are looking for a PhD student to work on a new generation of materials to extend the lifetime of these 'hyperpolarized' MRI tracers to days which will potentially lead to a radical democratization of the method. Your project will be at the interface between organic and material chemistry, and will involve the design, synthesis, characterization, and testing of novel porous materials based on hybrid organic-inorganic silicas.

Work Context

The successful candidate will evolve in a very interdisciplinary environment, and interact with chemists, biologists and physicists.

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