Reference : UMR5253-SEBBLA-001
Workplace : MONTPELLIER
Date of publication : Friday, April 29, 2022
Scientific Responsible name : Blanquer
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 5 September 2022
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
Cardiovascular diseases are one of the leading causes of death accounting for 31% of all deaths worldwide. Among the various consequences, the Aortic Aneurysm (AA) is one of the most frequent. AA consists in an increase of the aorta diameter leading to its expansion and rupture.
Endovascular prostheses are a satisfactory solution in surgery but have several limitations such as the time of generic manufacturing and the design that does not consider the complexity and uniqueness of human anatomy. 3D additive manufacturing brings a disruptive vision in this biomedical field with the possibility to develop custom-made endoprosthesis for cardiovascular surgery.
The thesis subject is part of a large-scale national project involving several partners from industrial and academic institutions which aims to develop smart and personalized cardiovascular endoprosthesis for AA treatment. This project
includes the synthesis of smart and hemocompatible polymers, optimization of the 3D fabrication process and finally determine their mechanical properties and study their biocompatibility and
stability over time in order to meet the specific specifications of the cardiovascular medical device.
This multidisciplinary project combines polymer chemistry, 3D additive manufacturing and biology with a perspective to answer to the crucial expectations in cardiovascular surgery. This project will be carried out at the Charles Gerhardt Institute in Montpellier, expert in polymer chemistry and additive manufacturing for health.
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