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Reference : UMR5248-PATDUL-012
Workplace : PESSAC
Date of publication : Wednesday, March 11, 2020
Scientific Responsible name : Habenstein Birgit
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 15 April 2020
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
Membrane damage is an insult to cells, occurring for example during viral infection. The PhD project inscribes itself into an interdisciplinary approach involving laboratories in France and Germany to study how viruses inflict membrane damage as port of entry into cells. The PhD candidate will use state-of-the-art static and Magic-Angle spinning solid-state NMR methods in conjunction with complementary biophysical techniques (Electron Microscopy, solution NMR, …), to characterize the underlying structural mechanisms of the molecular interplay involving membrane lipids and the viral proteins at the atomic level. The advanced biophysical approach will allow visualizing the principles of protein-inflicted membrane damage on multiple scales and addressing all involved partner molecules.
Contexte de travail
This interdisciplinary project funded by the ANR will be carried out in the group 'NMR of Membranes and Protein Assemblies' located at the IECB (http://www.iecb.u-bordeaux.fr/) in collaboration with the group of Dr. Harald Wodrich, expert in virology of Adenovirus.
The thesis will take place at CBMN and IECB, dynamic and interdisciplinary research centers, located on the campus of the University of Bordeaux in France. The laboratory is perfectly equipped for the biophysical analysis of proteins and membranes and the institutes are equipped with technological platforms combining cutting-edge instrumentation and expertise in biophysical and structural biology.
Constraints and risks
The candidate will be introduced into health and safety procedures in accordance with the IECB regulations by the health and safety manager upon arrival.
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