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Reference : UMR5247-MICSMI-001
Workplace : MONTPELLIER
Date of publication : Thursday, April 22, 2021
Scientific Responsible name : Michael Smietana/Christophe Mathé
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
The recruited PhD student will work in the GAVO - Generation of Original Antivirals - research program bringing together a French consortium of 3 organic chemistry laboratories specialized in the synthesis of nucleosides and nucleic acids supported by a molecular modeling team
In this context, the synthesis of nucleosides modified on the sugar moiety, on the heterocyclic part or at the glycosidic bond will be the main objective of this research work. The project aims to build libraries of molecules combining original and modular scaffolds with potential antiviral activity.
The antiviral evaluation of these analogues will be performed by a dedicated platform on a large panel of viruses.
The current pandemic of Covid-19 reminds us of our vulnerability to viruses, and more particularly to emerging RNA viruses (SARS-CoV-2, Zika virus, Dengue virus, Chikungunya virus, Ebola virus, …). Along with a prophylactic approach (vaccines), the development of antivirals capable of inhibiting viral RNA polymerase, which plays a central role in the viral replication cycle, is another therapeutic approach. Inhibition of RNA polymerase by means of small chemical molecules is an essential strategy which complements vaccination, aiming at offering an effective curative treatment of severe forms of the disease. As such, nucleoside analogs, known for their multiple applications in antiviral treatments and their potential in antiviral chemotherapy for decades, could provide an effective therapeutic response.
The candidate will possess good knowledge in organic synthesis and analytical chemistry (HPLC, mass spectrometry, NMR, ...). An experience in nucleosides and/or nucleic acid chemistry would be appreciated.
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