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Doctorant (H/F)

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : mardi 6 décembre 2022

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General information

Reference : UMR5239-ISASER-018
Workplace : LYON 07
Date of publication : Tuesday, November 15, 2022
Scientific Responsible name : Daniel JOST
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 16 January 2023
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

Context :
Inside the cellular nucleus, DNA is tightly packed into a polymer-like structure called chromatin. Characterizing how chromatin self-organizes is one of the major challenges faced in recent years by biology. During the last decade, thanks to the development of advanced experimental techniques, major progresses have been realized in our understanding of the multi-scale chromosome organization during interphase. An increasing number of experimental evidences has suggested that the spatio-temporal organization of the genome may play a decisive role in the regulation of gene expression and in diseases. It is therefore of high importance to better characterize the mechanisms driving such organization. In particular, a conserved principle is the folding of the genome into loops by active translocating motors such as condensin and cohesin. However, the nature and the consequences of the interplay between such DNA-binding motors and chromatin remain largely unknown.
In this project, we aim to address that question by focusing on the condensin complex during mitosis using an interdisciplinary approach.

Topic :
The student will develop a research activity on the modeling of chromosome folding and dynamics in eukaryotes to better characterize the role of histones and other chromatin-binding proteins in regulating the condensin loop extrusion activity. It will involve the development of original models coupling statistical and polymer physics, of efficient simulation schemes, and of statistical tools to analyze experimental data. The project will be realized in close collaboration with the group of Pascal Bernard for experimental biology (LBMC, ENS de Lyon) and Olivier Cuvier (CBI, Toulouse) for data analysis.

Candidate :
We are looking for a creative and highly motivated candidate with a Master in statistical or polymer physics, in computer science or in computational biology. Advanced skills in programming are required and a previous interdisciplinary experience in connection with biological issues would be a plus.

Work Context

The candidate will be supervised by Daniel Jost (DR CNRS) and will integrate the team 'Physical Biology of Chromatin' that mainly focuses on understanding the fundamental bases of chromatin and gene regulation using physical modeling and computational approaches. The team research is conducted in close interaction with top-leader experimental partners. The group is integrated within the Laboratory of Biology and Modeling of the Cell that aims to characterize the molecular bases underlying the organization and functioning of cellular processes in normal and pathological conditions. It is based at Ecole Normale Supérieure de Lyon, a French top-leading research and educational institute.

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