PhD student in modeling for biology (M/F)
New
- FTC PhD student / Offer for thesis
- 36 mounth
- BAC+5
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Laboratoire de Biologie et Modélisation de la Cellule
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
69364 LYON 07
Contract Duration
36 mounth
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 03 June 2026 23:59
Job Description
Thesis Subject
The Polycomb machinery is essential in regulating gene silencing during embryogenesis and development, through the coordinated action of transcription factors, histone modifying enzymes and architectural proteins. The initiation of several pediatric brain cancers has been associated with perturbations in such a machinery, which have important system-scale consequences on gene regulation. While the molecules whose functions may be impaired have been identified, how such an impairment affects mechanistically gene expression locally and at the systems scale remains elusive. In this project, we aim to address that question using an interdisciplinary approach.
Using mathematical modeling and data analysis in close collaboration with experimentalists, we aim at characterizing Polycomb regulation in normal and pathological conditions in order to better understand the systemic relation between metabolism, Polycomb machinery, genome organization and gene expression in the context of neural development. It will involve the development of original models coupling statistical physics, of efficient simulation schemes, and of statistical tools to analyze experimental data. This project is a direct collaboration between the groups of Daniel Jost (CNRS, ENS de Lyon; modeling) and Giacomo Cavalli (CNRS, IGH, Montpellier; experiments).
Your Work Environment
The candidate will be co-supervised by Daniel Jost and Cédric Vaillant at ENS de Lyon and Giacomo Cavalli at IGH. The student will be mainly located in Lyon but will visit regularly the Cavalli's group to foster exchanges with experimentalists. More broadly, this project is part of a national effort to characterize cell derailment in pediatric brain cancer via the consortium Cell-ID. Practically, the student will integrate the team 'Physical Biology of Chromatin' at ENS de Lyon that mainly focuses on understanding the fundamental bases of chromatin and gene regulation using physical modeling and computational approaches. The group is integrated within the Laboratory of Biology and Modeling of the Cell that aims to characterize the molecular bases underlying the organization and functioning of cellular processes in normal and pathological conditions. It is based at Ecole Normale Supérieure de Lyon, a French top-leading research and educational institute.
Constraints and risks
-
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR5239-CHRCHA-006 |
|---|---|
| CN Section(s) / Research Area | Modélisation mathématique, informatique et physique pour les sciences du vivant |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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