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Reference : UMR5229-JEADUH-003
Workplace : BRON
Date of publication : Thursday, July 23, 2020
Scientific Responsible name : Jean-René Duhamel
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 September 2020
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
Anatomy and function of the primate oxytocinergic system.
Oxytocin (OT) is a neurohormone known to play an essential role in social behavior in humans and other animals, by affecting the activity of specific neural populations. This doctoral project will study OT signaling in an animal model, the non-human primate, by pursuing 2 complementary lines of research to obtain innovative information on (i) the anatomical OT neural circuits, using a 3D light-sheet microscopy method after immunohistochemistry and tissue removal of brain blocks in series (ii) the social stimuli that activate hypothalamic OT neurons and behavioral consequences downstream of OT release by recording and manipulating their activity during behavioral tasks with electrophysiological and chemogenetic tools. The proposed research will use multiscale approaches involving cutting edge ex-vivo and in-vivo techniques and will reveal the neural pathways through which OT shapes social behavior.
The laboratory is an internationally recognized multidisciplinary research site in the field of cognitive neuroscience. The selected candidate will have the role of "lab manager" within the research team and will ensure the daily monitoring of the project under direct supervision by the principal investigator.
Constraints and risks
Experimentation on non-human primates
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