M/F PhD on the physical modeling of bacterial DNA segregation
New
- FTC PhD student / Offer for thesis
- 36 mounth
- BAC+5
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Laboratoire Charles Coulomb
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
34095 MONTPELLIER
Contract Duration
36 mounth
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 20 April 2026 23:59
Job Description
Thesis Subject
In bacteria, DNA segregation mainly relies on ParABS systems to faithfully partition DNA molecules at cell division. Our objective is to achieve a holistic, quantitative and molecular understanding of the mechanism driving the main bacterial DNA segregation system by using integrative and multidisciplinary approaches. We will perform physical modeling using the tools of theoretical physics. Our collaborators in the team of Jean-Yves BOUET (CBI, Toulouse) will perform experiments in genetics and genomics, cell biology and biochemistry to test our predictions. Built on an established collaboration, we intent to decipher the mechanisms that (i) drive the auto-assembly of the nucleoprotein complexes (ParB proteins) involved in the partition of the archetypical ParABS system of the plasmid F in Escherichia coli. This part involves a phase separation of proteins on a polymer, and (ii) the subsequent splitting and positioning of complexes at either side of the division plane through ParA proteins. This will be done with both non-linear systems and stochastic approaches. We will investigate the cross talk between two dynamic auto-assemblies of ParA and ParB that ensure DNA segregation. This project is at the interface between polymer physics, colloid physics and active matter. We will use both numerical and analytical approaches.
Your Work Environment
Candidate background. The applicant will display a background in theoretical physics. He/she will have skills in numerical simulations (e.g., Monte Carlo methods) and in developing analytical calculations. A strong interest in biology is needed.
Academic context. The host ream in Laboratory Charles Coulomb is composed by 5 permanent researchers, PhD students and postdoctoral researchers working collaboratively on various topics of bacterial processes from the cellular scale with DNA organization, genetic translation, flagellar motors up to the scale of population dynamics. We have an established collaboration with Jean-Yves BOUET's team (LMGM, Toulouse) where molecular biology experiments will be conducted.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR5221-JEAWAL-006 |
|---|---|
| CN Section(s) / Research Area | Physical chemistry, theoretical and analytic |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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