Phd position M/F
New
- FTC PhD student / Offer for thesis
- 36 month
- BAC+5
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut de Biochimie et Génétique Cellulaires
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
33077 BORDEAUX
Contract Duration
36 month
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 23 July 2026 23:59
Job Description
Thesis Subject
Cohesin, cellular adaptation and genome dynamics: an integrated study in S. pombe
The objective of this research project is to explore the mechanisms of cellular adaptation to environmental changes in the yeast Schizosaccharomyces pombe. We hypothesise that rapid adaptive responses involve post-translational modifications (PTMs) of cohesin, a complex essential for chromatin structuring. These PTMs could remodel chromatin architecture by modulating the dynamics and functions of cohesin, thereby enabling the cell to adjust its transcriptional programme in response to stress.
The project is structured around a three-year thesis focusing on:
1. The systematic identification of PTMs induced by various environmental stresses (oxidative, osmotic, thermal, etc.).
2. The functional characterisation of these modifications on Cohesin and on the overall organisation of chromatin.
3. The study of their consequences on cell survival and gene expression.
Ultimately, this work aims to provide an in-depth understanding of the epigenetic and structural mechanisms that enable cells to orchestrate rapid adaptation to stress, and to establish a sustainable collaborative platform for the functional study of PTMs.
Your Work Environment
The Institut de Biochimie et Génétique Cellulaires (IBGC) is a research institute located in Bordeaux, France, and jointly operated by the CNRS and the University of Bordeaux. It conducts fundamental research in biochemistry, cell biology, and genetics, with a focus on understanding cell division, genome stability, chromosome dynamics, mitochondrial function, and the molecular mechanisms underlying human health and disease.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR5095-KILAUD-069 |
|---|---|
| CN Section(s) / Research Area | Mathematics and mathematical interactions |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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