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Reference : UMR5089-YOAROM-004
Workplace : TOULOUSE
Date of publication : Tuesday, June 8, 2021
Scientific Responsible name : Dr. Yoann Rombouts and Dr. Olivier Neyrolles
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
Tuberculosis (TB) is one of the ten leading causes of death in the world, and the leading cause of death due to a single infectious agent, Mycobacterium tuberculosis (Mtb). We have recently identified the Dendritic Cell ImmunoReceptor (DCIR) as a key player in the immune and inflammatory response induced by Mtb. This thesis project aims to study precisely the function of DCIR in the anti-mycobacterial immune response at the molecular, cellular and organismal levels. The candidate will also be responsible for generating synthetic therapeutic antibodies and/or ligands that target DCIR and testing their therapeutic potential during Mtb infection. This project will provide fundamental knowledge and key molecular tools for the development of new therapies not only against tuberculosis, but also against other inflammatory diseases.
The thesis will be supervised by Dr. Yoann Rombouts, CNRS Researcher, and Dr. Olivier Neyrolles, CNRS Research Director, in the team "Mycobacterial interactions with host cells" of the Institute of Pharmacology and Structural Biology (IPBS), in Toulouse, France.
The IPBS is a joint research center of the CNRS and the University of Toulouse in the heart of the main campus of the University Toulouse III-Paul Sabatier, which offers high-level multidisciplinary training in the fields of science, health and engineering. The IPBS currently hosts more than 250 scientific and administrative staff, including more than 40 PhD and Postdoc of multiple nationalities. The IPBS currently includes 16 research groups working in the fields of inflammation, infections and cancer, as well as 4 state-of-the-art platforms in proteomics, biophysics and structural biology, molecular and cellular imaging and functional exploration, including BSL-3 laboratories for the study of infectious diseases (tuberculosis, AIDS, COVID-19).
Within the IPBS, the research of the team "Mycobacterial interactions with host cells" aims at understanding host-pathogen interactions in tuberculosis at the molecular and cellular levels, from the discovery of new virulence genes in Mycobacterium tuberculosis to the identification of immune mechanisms involved in host defense against the pathogen, with the overall objective of proposing better strategies to control the disease.
In addition to the experimental work, the PhD student will participate in weekly team meetings, seminars at the institute, and national or international conferences. In addition, a thesis committee will be set up to monitor the progress of the PhD student's research.
Constraints and risks
As Mycobacterium tuberculosis is a human pathogen, a large part of the candidate's work will be performed in a biosafety level 3 laboratory and animal facility.
We are looking for a candidate
- With a strong background in immunology and pathophysiology.
- Motivated by in vivo experimental approaches in mice, flow cytometry and cell biology. Experience in animal experimentation would be a plus.
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