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PhD on immunity to infections M/F

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : jeudi 25 août 2022

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General information

Reference : UMR5089-ETIMEU-003
Workplace : TOULOUSE
Date of publication : Thursday, August 4, 2022
Scientific Responsible name : Etienne Meunier
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2022
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

PathophySiological impact of Inflammasome COntrol by PAK-kinases in psoriasis

By affecting more than 3% of adults in the human population, psoriasis is one of the most common skin diseases. Evidence of genetic predisposition has emerged with the association of inflammasome members NLRP1 and NLRP3 polymorphisms with higher risk of psoriasis. In addition, RhoGTPases dysregulation have been also associated with plaque of psoriasis in humans. Rac1 is found highly active in human psoriatic lesional skin and keratinocytes, and keratinocyte-specific overexpression of an activated mutant of Rac, in a transgenic mouse model closely mimics the presentation of human psoriasis. Interestingly, the link between Rac activation, inflammasomes and the inflammatory psoriasis-like phenotype observed in mice is still unclear. Our hypothesis is that the Rac-Pak-inflammasome signaling axis determines the psoriasis-like phenotype observed in mice as well as psoriasis in humans and could be a novel target to treat psoriasis in patients. Here, based on solid preliminary data, we propose a multidisciplinary consortium that will dissect the Pak1 regulation of inflammasomes in the context of psoriasis at the molecular level, in vivo using mice genetic model as well as in patient's samples.

Work Context

The IPBS is a multidisciplinary research institute whose themes range from understanding the molecular mechanisms governing living organisms to physiopathological implications including cancer, infections, inflammation.
The subject proposes to specifically address the study of a new inflammatory complex and the interactions between this complex and susceptibility to microbial infections, but also its involvement in the development of pulmonary and cutaneous pathologies (psoriasis).

Constraints and risks

The student will be taken to work on class 3 viruses (SARS-CoV2, Influenza), class 2 bacteria (Pseudomonas, S. aureus, C. violaceum, B. cenocepaciae, M. abscessus, F. novicida ) and 3 (M. tuberculosis) in restricted access areas

Additional Information

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