PhD (M/F): development of single-cell proteomics methods for the study of neuroinfections and the immune response
New
- FTC PhD student / Offer for thesis
- 36 month
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut de Pharmacologie et Biologie Structurale
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
31077 TOULOUSE
Contract Duration
36 month
Date of Hire
17/08/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 20 July 2026 23:59
Job Description
Thesis Subject
This methodology-driven PhD aims to develop and validate a coherent set of methods for single-cell proteomics (SCP) by mass spectrometry, spanning the entire analytical chain: lossless cell isolation and preparation (CellenONE robot), high-sensitivity and high-throughput acquisition (timsTOF SCP, Orbitrap Astral), and bioinformatic processing of the data. The challenge is to push back the field's frontiers (sensitivity, depth, throughput and spatial resolution) jointly, for small primary cells.
The methods developed will be tested on two complementary biological applications. The main application, the ProteoVir project (CNRS "Recherche à risque et à impact" program), focuses on spatial single-cell proteomics of neuroinfections: mapping, while preserving tissue topography, the impact of neurotropic viral infections on the proteome of individual cells (neural models, brain organoids). The secondary application focuses on the fine-grained modulation of the proteome of immune cell subpopulations during the immune response.
Your Work Environment
The PhD will take place at the Institute of Pharmacology and Structural Biology (IPBS, UMR 5089, CNRS / University of Toulouse), within the "Proteomics and Mass Spectrometry of Biomolecules" team led by Odile Schiltz. This team hosts the ProteoToul platform and is one of the nodes of the national proteomics infrastructure ProFI. With around twenty staff of complementary expertise (mass spectrometry, biochemistry, bioinformatics), it is equipped for single-cell proteomics: a CellenONE isolation and preparation robot, Evosep chromatographic systems, ultrasensitive timsTOF SCP and Orbitrap Astral Zoom mass spectrometers, and a dedicated bioinformatics environment.
The PhD will be supervised by Odile Schiltz (HDR, thesis director) and Anne Gonzalez de Peredo (co-supervisor). It will be part of a national collaborative environment, alongside the other ProFI nodes (Grenoble and Strasbourg) and the collaborating teams (IRIM, Montpellier; CIML, Marseille).
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR5089-ANNGON-005 |
|---|---|
| CN Section(s) / Research Area | Chemistry of and for life: design and properties of molecules of biological interest |
| Relevant experience | 1 to 4 years |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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