Description du sujet de thèse

The project is situated within the broader context of developing strategies to more effectively prevent and control the emergence of infectious diseases, within the framework of a larger consortium. Bunyaviruses represent several of the priority pathogens listed by the World Health Organization (WHO) as possible causes of future pandemics, including Crimean-Congo hemorrhagic fever virus (CCHFV), Lassa fever virus (LASV), and Rift Valley fever virus (RVFV). These viruses currently emerge in southern parts of Europe. In this context, our objective is to contribute a molecular understanding of the mechanisms of infection.

The objective of the PhD is to examine the structures and interactions between the membrane-bound proteins of these viruses. To achieve this, the PhD will utilize mainly proton-detected solid-state NMR spectroscopy, but also other biophysical approaches, to examine the samples she/he prepared using biochemical techniques that are well-established in the lab. The PhD will work closely with other lab members involved in different aspects of this larger project.

Activities include:
- Protein preparation using cell-free protein synthesis, design dedicated labeling variants
- Biophysical characterization, including of interactions
- NMR measurements
- Spectra analysis
- Data interpretation
- Promotion of results through publications and participation in conferences
- Drafting of reports, technical documents and scientific publications

We are looking for highly motivated, talented and ambitious young scientists to join our collaborative and enthusiastic team. We offer an excellent scientific environment. The successful candidate should have a degree in structural biology, biochemistry, biophysics and should be proficient in protein NMR, liquid or solid-state, and NMR data analysis. We offer a welcoming environment with a friendly and satisfying working atmosphere, excellent facilities, a workplace with all the benefits of public service, as well as training and development opportunities.
Salary is in accordance with CNRS regulations. The position will commence May 1st 2026.

Contexte de travail

The laboratory is located within the Molecular Microbiology and Structural Biochemistry unit (MMSB) in the Lyon Gerland district, in close proximity to the city center and with convenient access to public transportation, including the subway, tram, and cycle paths. As the second largest city in France, Lyon is a prominent center for research on viral disease, and the project is anchored in a collaborative network including virologists and structural biologists from different horizons.

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.

Contraintes et risques

NA