Ph.D. in Computational Systems Biology / Bioinformatics (M/F)
New
- FTC PhD student / Offer for thesis
- 36 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Unité de biologie moléculaire, cellulaire et du développement
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
31062 TOULOUSE
Contract Duration
36 months
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 31 July 2026 23:59
Job Description
Thesis Subject
The DISCOVER ME project, funded by the Horizon Europe program, marks the launch of the first European Horizon Europe project specifically dedicated to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ME/CFS is a severe, chronic, and often profoundly disabling illness. To date, its diagnosis relies exclusively on clinical criteria, which frequently results in long delays in diagnosis and places a significant burden on those affected.
The doctoral student will work on mapping EM/CFS and conducting in silico simulations using large-scale logical models. To do so, he or she will need to :
- Develop a comprehensive, computable disease map of ME/CFS, based on multi-omic data and clinical phenotypes, in accordance with Systems Biology Graphical Notation (SBGN) standards.
- Conduct multimodal integrative analyses of validated datasets, focusing on the convergent mechanisms and interactions involved in the pathophysiology of ME/CFS.
- Generate and prioritize new, data-driven hypotheses regarding the causality of the disease and therapeutic targets, using the map-to-model framework.
- Model the heterogeneity of the disease and its progression over time, particularly differences among patient subgroups, to better understand the variability in clinical trajectories and treatment responses.
The successful candidate must :
- Hold a master's degree in bioinformatics, computational biology, or a related field.
- Have experience analyzing omics data, particularly scRNA-seq and/or bulk data.
- Have experience in computational modeling of complex human diseases: agent-based models, Boolean models, and ordinary differential equation models.
- Have programming skills in R and Python.
- Possess strong analytical skills and the ability to work across disciplines.
- Have a very good command of English.
- Be able to work in an interdisciplinary and international environment.
Your Work Environment
As part of the DISCOVER ME program, a Ph.D. position is available at the Center for Integrative Biology (CBI) in Toulouse, a joint CNRS–University of Toulouse research unit dedicated to integrative biology at various scales. The successful candidate will join the Systems Biology division within UMR5077 - MCD and will be supervised by Prof. Anna Niarakis.
https://cbi-toulouse.fr/en/equipe/pole-de-biologie-des-systemes-en/
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR5077-MARPEL1-024 |
|---|---|
| CN Section(s) / Research Area | Molecular and structural biology, biochemistry |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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