Doctorate (M/F) in Moleulcar biology: DNA repair
New
- FTC PhD student / Offer for thesis
- 36 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Unité de biologie moléculaire, cellulaire et du développement
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
31062 TOULOUSE
Contract Duration
36 months
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 31 August 2026 23:59
Job Description
Thesis Subject
This project is funded by an ANR JCJC and focuses on the repair of DNA breaks with non-canonical ends, particularly 5'OH ends. DNA breaks account for approximately 75% of all DNA lesions and often have so-called "dirty" ends (lacking 5' phosphate or 3' hydroxyl groups), with atypical chemical modifications (e.g., 5'hydroxyl, 5'aldehyde, 3'phosphate, etc.). These ends must be processed or repaired to restore DNA integrity, but this process increases the risk of errors, thereby promoting genomic instability. However, the way these "dirty" breaks contribute to this instability remains poorly understood, despite its critical importance for assessing their impact on human diseases such as aging, neurodegenerative diseases, or cancer.
Among the most frequent breaks are those with 5'hydroxyl (5'OH) ends. These breaks are caused by exogenous sources (e.g., irradiation, chemotherapeutic agents like camptothecin) or endogenous sources (e.g., cellular metabolism via reactive oxygen species or the activity of Topoisomerase 1). This PhD project aims to answer a key question: How do 5'OH breaks contribute to genomic instability? This will be investigated using various genomic approaches.
Your Work Environment
The recruited individual will be supervised by researcher Aline Marnef. The research will be conducted within the team led by Gaëlle Legube, which is internationally recognized for its major advancements in the field of DNA damage repair. www.legubelab.com
The team is based at the Centre de Biologie Intégrative (CBI, Toulouse), a large-scale research hub bringing together nearly 400 people working on diverse topics. The CBI is located on the campus of Université Paul Sabatier. https://cbi-toulouse.fr/
Constraints and risks
Risk related to chemical products
Risk related to biological agents
Risk related to work equipment
Risk related to isolated work
Risk related to screen work
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR5077-ALIMAR-002 |
|---|---|
| CN Section(s) / Research Area | Organisation, expression and evolution of genomes Bioinformatics and systems biology |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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