PhD Fellowship in Neuroimmunology (M/F) - Toulouse Institute for Infectious and Inflammatory Diseases (INFINITY)
New
- FTC PhD student / Offer for thesis
- 36 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut Toulousain des Maladies Infectieuses et Inflammatoires
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
31024 TOULOUSE
Contract Duration
36 months
Date of Hire
01/12/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 19 November 2026 23:59
Job Description
Thesis Subject
The central nervous system has long been considered an “immune-privileged” site, where immune activity is tightly restricted. However, accumulating evidence indicates that active and dynamic mechanisms continuously regulate immune cell infiltration and function within the brain. In particular, T-cell activity is finely tuned by regulatory pathways that control activation, differentiation, and tissue adaptation. While these mechanisms are well characterized in peripheral inflammatory contexts such as cancer and infection, their roles in healthy tissues, and especially within the central nervous system, remain poorly understood. Based on recent preliminary data generated in our team, we hypothesize that regulation of TCR signaling orchestrates both the entry and functional programming of T cells within the central nervous system, acting as a key determinant of its immune landscape at steady state. This PhD project aims to dissect the molecular and cellular mechanisms that control these processes in the CNS, and to determine how their dysregulation impacts immune homeostasis, susceptibility to neuroinflammatory disease, and cognitive function. The project will combine cutting-edge approaches in immunology and systems biology, including spectral flow cytometry, omics analyses (scRNA-seq, proteomics), and behavioral testing in murine models. This PhD is positioned at the interface between immunology, neuroscience, and systems biology, within a highly interdisciplinary research environment.
Your Work Environment
Completion of the thesis will be at the Infinity institute located in Toulouse, France. Project will be supervised by Renaud Lesourne in the team Integrative mapping of lymphocyte signaling and function.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR5051-RENLES-004 |
|---|---|
| CN Section(s) / Research Area | Host-pathogen relationship, immunology, inflammation |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
Create your alert
Don't miss any opportunity to find the job that's right for you. Register for free and receive new vacancies directly in your mailbox.