PhD Offer in biochemistry (M/F) How Crip1a and PUFAs shape the signaling of the CB1R GPCR, a structural view by NMR and modelling
New
- FTC PhD student / Offer for thesis
- 36 months
- BAC+3/4
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Centre de biologie structurale
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
34090 MONTPELLIER
Contract Duration
36 months
Date of Hire
01/01/2027
Remuneration
2300 € gross monthly
Apply Application Deadline : 21 August 2026 23:59
Job Description
Thesis Subject
Deciphering the biased signaling of a GPCR by integrative structural biology
Your Work Environment
Applications are invited for a full-time PhD position (36 months) at the Centre de Biologie Structurale (CBS) in Montpellier. The position is funded by ANR and will be carried out under the supervision of the project scientific manager.
This PhD project aims to decipher how the Crip1a protein modulates CB1R signaling through long-range allosteric interactions and in synergy with specific lipids, namely PUFA-PL. This modulation alters the receptor's conformational landscape and thereby determines the selectivity towards specific Gαi protein subtypes.
Building on recent advances in protein purification ad specific labelling with non natural amino acids, the project will explore the details of the interaction at atomic resolution, including the full length receptor. The goal is to understand the structural and dynamic properties of the complex, the impact of the lipid environment and this will be addressed using advanced NMR methods. and integrative modelling, providing real- insights into conformational changes governing CB1R selectivity.
This project offers the opportunity to contribute in the long term to the rational design of selective compounds of pharmacological interest.
Constraints and risks
We are looking for highly motivated recent Master 2 students with expertise in areas such as:
-structural biology, especially NMR
-protein purification.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR5048-LIDSCO-009 |
|---|---|
| CN Section(s) / Research Area | Mathematics and mathematical interactions |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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