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Reference : UMR5048-FLOLEP-023
Workplace : MONTPELLIER
Date of publication : Thursday, July 22, 2021
Scientific Responsible name : Francesco PEDACI
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
We are looking for strong and motivated candidates to fill one PhD position (3 years) in the group Physics and mechanics of biological systems at CBS Montpellier, France.
Our project aims at understanding from an experimental biophysics perspective the mechanisms driving the activity and complex dynamics of the Bacterial Flagellar Motor, the powerful protein complex found at the base of the flagellum in many motile bacteria. Rotating on its axis, the motor is responsible for the continuous rotation of flagella and propulsion of the cell. Within our international consortium, we will probe the behavior of individual motors in bacteria that evolved to produce high torque, with the aim to reveal how the complex motor mechanisms and structure evolved.
The ideal PhD candidate will have a Master (or equivalent) degree in Physics or life sciences with a strong quantitative background, experience in one or more of the following points, and an interest in interdisciplinary projects.
• single-molecule biophysics
• microscopy and fluorescence microscopy
• programming, quantitative data analysis and
• theoretical modeling
• wetlab techniques and cell/molecular biology (bacterial genetic manipulations, protein purification)
• demonstrated ability to work both independently and within a team
• Good English oral and written communication skills (French is not a requirement)
The project is in collaboration between the Hochberg Lab at the Max Planck Institute in Marburg (evolutionary biochemistry), the Beeby lab at Imperial College London (cryo electron tomography), and the Cary Lab at Waikato University in New Zealand (metagenomics). This collaboration is funded by a highly competitive Human Frontiers grant, with funding for 3 years.
CBS is a strong interdisciplinary lab with a rich spectrum of expertise ranging from biophysics to synthetic and structural biology. Our group develops and employs novel single-molecule biophysics techniques such as optical and magnetic manipulation and single-molecule fluorescence microscopy, as well as theoretical analysis and modeling.
Please submit an application, including CV, cover letter, and the names of 2-3 references.
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