Thesis - An innovative combination of experimental and modeling approcaches to assess the role of amibes in the spread of antibiotic resistance in soil (M/F)
New
- FTC PhD student / Offer for thesis
- 36 months
- BAC+5
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut des géosciences de l'environnement
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
38400 ST MARTIN D HERES
Contract Duration
36 months
Date of Hire
01/11/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 28 July 2026 23:59
Job Description
Thesis Subject
Antibiotic resistance (ABR) is a global threat affecting human, animal, and environmental health. Limiting its environmental reservoirs
requires a better understanding of its pathways of dissemination. While wastewater and surface water have been well studied, the role of
soil remains largely unexplored. Soils are, however, major reservoirs of antibiotic-resistant bacteria (ARBs) carrying antibiotic resistance
genes (ARGs). In this terrestrial environment, protists (micro-eukaryotes), particularly amoebae, play an important role in regulating
bacterial populations through their predatory activity. However, certain bacteria—including opportunistic pathogens such as ARBs—resist
amoebic lysis after phagocytosis and thus persist within the amoebic microbiota. Amoebae could thus play a key role as vectors of
antibiotic-resistant bacteria (genes) (ARBs/ARGs). Through an integrated interdisciplinary “One Health” approach, this thesis proposes to
study the influence of soil properties on the survival and mobility of amoebae, ARBs, and ARGs (molecular labeling). An innovative
combination of experiments and modeling (reactors, soil cores, X-ray tomography, hydrobiogeochemical model) will enable the
quantification of their transport in the soil and the prediction of the risk of AMR dissemination.
Your Work Environment
The Institut des Géosciences de l'Environnement (IGE, http://www.ige-grenoble.fr) is a French public research establishment under the supervision of CNRS Terre & Univers, IRD, Université Grenoble Alpes (UGA), Grenoble-INP and INRAE. It employs some 330 people, including 190 permanent members (researchers, associate and full professors, research engineers), and around 140 PhD students, post-doctoral researchers and staff on fixed-term contracts. The Institute also welcomes several dozen interns and visiting scientists every year. The Institute is located on three sites on the Grenoble University Campus (Molière, OSUG-B and Maison Climat Planète). The IGE is one of the main laboratories of the Observatoire des Sciences de l'Univers de Grenoble (OSUG), a federative structure of the Institut National des Sciences de l'Univers (INSU) of the Centre National de la Recherche Scientifique (CNRS).
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR5001-ALEVIA-054 |
|---|---|
| CN Section(s) / Research Area | Continental surface and interfaces |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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