PhD IN BIOLOGY : Deciphering the role of microtubule polyglutamylation in tau protein-related neurodegeneration (M/F)
New
- FTC PhD student / Offer for thesis
- 36 months
- BAC+5
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Genome, ARN et Cancer
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
91401 ORSAY
Contract Duration
36 months
Date of Hire
01/01/2027
Remuneration
2300 € gross monthly
Apply Application Deadline : 17 August 2026 23:59
Job Description
Thesis Subject
The microtubule cytoskeleton exerts multiple functions in neurons that need to be continuously regulated to ensure neuronal homeostasis. The structure and function of microtubules are regulated by tubulin post-translational modifications. Polyglutamylation is a modification that is highly enriched in neuronal microtubules. Our team has shown that polyglutamylation controls axonal transport and interactions between microtubules and various microtubule-associated protein (MAPs). One of the MAPs sensitive to polyglutamylation is tau protein, implicated in the pathogenesis of neurodegenerative disorders called tauopathies. But the specific causal relationship and molecular mechanism between microtubule polyglutamylation and tau pathology have not been clarified.
In this project, we will address this issue by characterising novel murine models already available in our lab, investigating effects on primary neurons derived from those mouse models, and analysing patient material. We will also explore whether changing polyglutamylation levels by manipulating polyglutamylating enzymes can mitigate the degenerative phenotypes.
Overall, this study aims to decipher the role of tubulin polyglutamylation in the genesis of tau protein-related neurodegeneration. Our results will lay the ground for the development of therapeutic strategies for microtubule-related neurodegenerative diseases and tauopathies
Your Work Environment
This project will be carried out in the Institut Curie, and the student will have free access to all available core facilities and technology platforms in Orsay and Paris. For this project in particular, we will use the transgenic mouse facility, imaging facility, and the L3 laboratory. All equipment and technology needed for this project is in place, and the methodology is firmly established in our team.
Our team has received diverse funding including from the ERC or ANR that will fully cover the expenses of the planned research throughout the entire period of the thesis. We also plan to apply for funding of a project partially overlapping with this proposal to France Alzheimer programme.
Constraints and risks
None
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR3348-PASLEO-013 |
|---|---|
| CN Section(s) / Research Area | Molecular and cellular neurobiology, neurophysiology |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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