PhD student, molecular and cellular biology (M/F)
New
- FTC PhD student / Offer for thesis
- 36 mounth
- BAC+5
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Génétique et biologie du développement
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
75248 PARIS 05
Contract Duration
36 mounth
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 15 May 2026 23:59
Job Description
Thesis Subject
The leading genetic cause for Atypical Teratoid/Rhabdoid Tumors is the mutation of Smarcb1. Yet, inactivation of this gene in many cell lines impairs cell proliferation and is strongly counter selected. Moreover, we have shown that a specific developmental context is required for SMARCB1 to promote cell proliferation. This raises the question of what control the cellular outcome of SMARCB1 inactivation.To tackle this question, we propose to engineer various models of acute inactivation of Smarcb1 (CRISPRi & degron) and to perform genetic screens to identify genes whose altered expression enable cells to survive the deletion of SMARCB1. We will then investigate how those genes are regulated during development, in particular at the phase when ATRT is thought to arise. We will manipulate their expression in ATRT cell lines and PDX to determine their contribution to tumorigenesis. Finally, we will use our model of SMARCB1 acute degradation to investigate its direct and early targets genes (CUT&RUN, TT-seq, HiChIP, Proteome) and further investigate its mechanism of action.
Your Work Environment
The doctoral student will be based at UMR3215 on the Institut Curie campus (Paris 05) and will work under the supervision of R. Margueron. The student will be affiliated with the Complexité du Vivant doctoral school (CDV515). This position is part of the PEPR Cell-ID program.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR3215-RAPMAR-001 |
|---|---|
| CN Section(s) / Research Area | Organisation, expression and evolution of genomes Bioinformatics and systems biology |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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