Dialogue between the brain and peripheral tissues for the control of energy homeostasis throughout life M/Fe tout au long de la vie H/F

Job Description

Summary of the scientific project

The scientific project aims to strengthen the leadership position of the BFA laboratory in the field of integrated physiology, in relation to nutrition, the regulation of energy homeostasis, and their pathological disorders. Focusing on the theme of peripheral/brain interactions, the project will explore gut-brain interactions, particularly the role of the vagal and central nervous systems in controlling eating behavior. It will also include the study of sensory signals (food odors) and circulating signals (nutrients, hormones such as incretins) on the regulation of blood sugar and insulin secretion. These two areas can be combined for an integrated approach using preclinical models of diabetes and obesity. The project will be based on a multidisciplinary approach (cellular, molecular and behavioral tools) and will have a translational focus to enhance the clinical impact of the research conducted.

Summary of the teaching project

The teaching program focuses on neurophysiology, a major strategic challenge for the teaching and research missions of the Life Sciences Department (SdV). The courses will not only support the teaching of animal physiology, but also ensure continuity and pedagogical quality in several teaching units (UE) at the Bachelor and Master levels, including those taught in English and the new international program 'Advances in Life Sciences'. The courses will cover both general UE (Integrative Animal Biology, Introduction to Neuroscience) and more specialized UE (Brain and Energy Metabolism, Development & Plasticity of the Nervous System). The candidate will supervise students from the BioScience Paris Santé doctoral school (Department of Physiology and Pathology) and will be required to submit their HDR or accreditation to supervise research to the Paris Cité University, if they do not already hold this qualification.

Potential host facilities

• INSB - CNRS Biologie
• BFA - Unité de biologie fonctionnelle et adaptative

Your Profil

Profile Required

Holders of a doctorate or a PhD or equivalent degree or applicants who have gained scientific qualifications or carried out scientific work deemed to be of an equivalent level.There is no restriction on the age or nationality of applicants. All CNRS positions are accessible to people with disabilities, with special arrangements for tests made necessary by the nature of the disability

Your Work Environment

Host Lab Strategy

The junior chair project is fully in line with the scientific strategy of the BFA unit (CNRS/Université Paris Cité), which studies the impact of the nutritional environment on organisms throughout the lifespan.
The successful candidate will reinforce the unit's core themes – while developing their own identity – particularly peripheral organ-brain interactions in energy metabolism control and their pathological alterations (obesity, diabetes, eating disorders). His/her program will focus on inter-organ interactions, particularly between the gut and brain via the vagal nervous system, or the study of sensory signals (food odors) and circulating signals (nutrients, hormones) on the regulation of blood sugar and insulin secretion. This project will rely on the expertise of the REGLYS and CO2FEE teams and will benefit from the site's technological platforms, clinical networks and structuring projects (Metabobrain, IHM Neurosciences, DiabetEX).

Institution Strategy

CNRS Biology's mission is to develop and coordinate biological research aimed at deciphering the complexity of living organisms, from atoms to biomolecules, from cells to entire organisms and populations. By targeting the physiological regulation of energy homeostasis, this project directly responds to the CNRS's ambition to bring together interdisciplinary approaches (neurology, nutrition, integrated physiology, chemistry, cognition) to address major societal challenges: healthy ageing, adaptation to modern nutritional environments and prevention of metabolic diseases (obesity, type 2 diabetes, eating disorders). Drawing on the multidisciplinary framework of the CNRS, the recruitment of a junior professorship (CPJ) on this theme will advance fundamental knowledge essential to understanding the molecular, cellular and physiological determinants by which the dialogue between the brain and organs coordinates the adaptive response to environmental changes to maintain energy balance throughout life. This issue is part of a broader vision of neuro-metabolic control of the physiological and pathophysiological aspects associated with metabolic disorders. This approach is also part of a structuring initiative that promotes the emergence of cross-disciplinary projects and consolidates the CNRS's position as a key player in fundamental and translational research in integrative biology.

International Strategy

The recruitment of this junior professorship (CPJ) will contribute to the thematic organisation of BFA, leading to the creation of a center of excellence focused on the study of neurometabolic control of energy balance. This approach is part of the international strategy of the unit and Paris Cité University, which aims to strengthen its attractiveness and influence abroad. The successful candidate will be encouraged to develop collaborations with laboratories abroad, within the framework of European projects (Horizon Europe, ERC) or bilateral partnerships, thereby enhancing the unit's international visibility. In addition, Université Paris Cité, through its joint degrees and exchange programs (Erasmus+, joint supervision of theses), offers an ideal framework for integration into international academic networks. Participation in European consortia or collaborative projects (such as those led by the REGLYS and CO2FEE teams) will broaden research perspectives and increase the impact of the work carried out.

Compensation and benefits

Compensation

Annual salary from 54 600 Euros to 57 800 Euros depending on professionnal experience.

Total funding

200k€

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

Research Policy

Open Science

The CNRS is developing a strong policy in favor of open science. Open science consists of making research results "as accessible as possible and closed as necessary". As such, the CNRS aims to make 100% of the texts of publications resulting from the work of its laboratories accessible , in particular through deposit in HAL. The data produced must also be made available and reusable, except for specific restrictions. In addition, the guiding principles of individual evaluation have been revised in accordance with the DORA declaration, to be more qualitative and to take into account all facets of the researcher's profession.

Science and society

The relationship between science and society is now recognized as a full dimension of scientific activity. The project will develop this dimension in synergy with all the partners. The resulting research work will contribute to informing public decision-making. Participatory science initiatives may be initiated with actors from the project’s socio-economic and cultural eco-system.

Scientific dissemination

The dissemination of the results will be done through world-class scientific productions: publications, patents, software... In addition, the results will be communicated to various targets such as scientific communities, media, decision makers, general public, schools, etc., with an adapted calendar. Specific tools may be developed such as websites, newsletters, meetings, international symposia, summer schools and conferences.

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

The research professions