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Holders of a doctorate or a PhD or equivalent degree or applicants who have gained scientific qualifications or carried out scientific work deemed to be of an equivalent level.There is no restriction on the age or nationality of applicants. All CNRS positions are accessible to people with disabilities, with special arrangements for tests made necessary by the nature of the disability

Institution Strategy

The host laboratory has extensive experience in the field of radiobiology and new approaches to radiotherapy. Guided by this experience, the CNRS (Biology) considers it crucial to strengthen this approach on this campus, which benefits from a particle accelerator that can be used for fundamental research.

Host Lab Strategy

The host laboratory has extensive experience in the field of radiobiology and new approaches to radiotherapy. Guided by this experience, the CNRS (Biology) considers it crucial to strengthen this approach on this campus, which benefits from a particle gas pedal that can be used for fundamental research.

International Strategy

This project offers a unique opportunity to understand the radiobiological molecular and cellular mechanisms underlying new types of radiotherapy, and to generate essential knowledge for optimizing their development and use.

National Directory of Research Structures (RNSR) of the host laboratory

Signalisation, Radiobiologie et Cancer (UMR3347)201019050T

Summary of the scientific project

The radiobiology project aims to characterize, at the molecular, cellular and organ levels, the impact of innovative radiotherapy methods on healthy and tumor tissues. Research will focus in particular on the effects of dose delivery on vascular regeneration and immune modulation of the tumor microenvironment. CPJ will have access to advanced molecular and cellular technologies (RNAseq on single cells, spatial transcriptomics, organoids and ex vivo models...) and will interact with experts in systems biology. The aim is to characterize the lesions induced by different types of radiation and delivery modes, and to model the repair and reorganization processes of the resulting tumor microenvironment.

Summary of the teaching project

Diploma on radiotherapy research currently being finalized under the guidance of Gilles Créhange, PU-PH at the Université Versailles-Saint-Quentin-en-Yvelines, and contributions to undergraduate biophysics courses at the same university.

Financial Environment

• Total (included package ANR) : 200 k€
• Total financement : k€

Scientific dissemination

The dissemination of the results will be done through world-class scientific productions: publications, patents, software... In addition, the results will be communicated to various targets such as scientific communities, media, decision makers, general public, schools, etc., with an adapted calendar. Specific tools may be developed such as websites, newsletters, meetings, international symposia, summer schools and conferences.

Open Science

The CNRS is developing a strong policy in favor of open science. Open science consists of making research results "as accessible as possible and closed as necessary". As such, the CNRS aims to make 100% of the texts of publications resulting from the work of its laboratories accessible , in particular through deposit in HAL. The data produced must also be made available and reusable, except for specific restrictions. In addition, the guiding principles of individual evaluation have been revised in accordance with the DORA declaration, to be more qualitative and to take into account all facets of the researcher's profession.

Science and society

The relationship between science and society is now recognized as a full dimension of scientific activity. The project will develop this dimension in synergy with all the partners. The resulting research work will contribute to informing public decision-making. Participatory science initiatives may be initiated with actors from the project’s socio-economic and cultural eco-system.

Indicators

The activity will be evaluated in particular on the basis of scientific production (publications, software, patents, etc.), on institutional and private partnerships formalized by contracts, on international presence, on the promotion of work to multidisciplinary scientific communities, on innovation and its transfer to society and on scientific dissemination to non-specialist audiences.

Methods of organization of the interviews

Only the candidates selected on file by the selection committee will be invited to the auditions.