Profil Recherché

Titulaire d’un doctorat ou diplôme équivalent ou justifiant de titres et travaux scientifiques jugés équivalents par l’instance compétente de l’établissement. Il n’y a aucune condition d’âge ou de nationalité pour candidater. Tous les emplois CNRS sont accessibles aux personnes en situation de handicap en bénéficiant d’aménagement d’épreuves rendus nécessaires par la nature du handicap

Stratégie d'établissement

The last two decades have seen the spectacular development of new experimental tools that allow the in situ visualization of the position, movement and assembly of living molecules. These techniques allow a time-dependent monitoring, at the molecular, cellular and multicellular scales, of tissues in formation and growth, or of organoids formed under realistic physiological conditions. The understanding of the fundamental laws underlying these biological phenomena, through experimentation and modeling, is at the heart of many scientific challenges in the decades to come. This is why the CNRS is setting up a concerted inter-institute action to promote the development of this field at the crossroads of physics, biology and mathematics. This interdisciplinary research should lead to a significant advance in the knowledge of the natural laws underlying the properties, functions and evolution of tissues and experimental biomimetic systems.

Stratégie du laboratoire d'accueil

The winner of this CPJ will be responsible for creating or strengthening interactions between the INP, INSB and INSMI laboratories at one of the following 4 geographical sites: Lyon, Marseille, Paris (Sorbonne Université) and Toulouse.

Stratégie Internationale

CNRS is a major player in international science. Throughout the world, CNRS teams collaborate with the best laboratories, and every year, high-level foreign researchers join the CNRS. These cooperative ventures, based on complementarity and emulation, ensure the continued progress of excellent research to meet the global challenges of the 21st century. CNRS also encourages and supports the development of international research projects, particularly at the European level (ERC and EIC) and collaborative exchanges (IEA, IRP, IRN).

Résumé du projet scientifique

Tissues are assemblies of interacting individual biological objects, from the molecular (DNA, proteins...), cellular (membrane channels, cytoskeleton network...) to the multi-cellular and tissue (mechanical) scales with complex feedback mechanisms crossing scales (e.g. mechano-transduction). The control of experimental model systems mimicking tissues, such as two- or three-dimensional organoids, as well as the integration of biological data obtained at different scales, allow the elaboration of physical models (taking into account molecular and mesoscopic interactions) that can be validated, informed or invalidated by mathematical simulations. These multi-scale models aim at reproducing in silico the main mechanisms of tissue evolution, and find their application -for example- in cancerology, by a better understanding of tumor evolution and the impact of treatments.

Résumé du projet d'enseignement

The candidate will have to propose a teaching project (42h) in line with the theme "Multiscale studies of biological tissues" and the interdisciplinary context of the position. This teaching project will then be discussed with the university supervisor of the host laboratory of the CPJ.

Environnement Financier

• Total financé (dont package ANR) : 200 k€
• Total du projet : 200 k€

Diffusion scientifique

The dissemination of the results will be achieved through scientific productions (publications, software, patents...) of world level. In addition, the project will implement a communication towards various targets such as scientific communities, media, decision makers, general public, schools, etc., with an adapted calendar. Specific tools will be developed such as websites, newsletters, meetings, international symposia, summer schools and conferences.

Science ouverte

The CNRS is developing a strong policy in favor of open science. Open science consists of making research results "as accessible as possible and as closed as necessary". As such, the CNRS aims to make 100% of the texts of publications resulting from the work of its units accessible, in particular through deposit in HAL. The data produced must also be made available and reusable, except for specific restrictions. In addition, the guiding principles of individual evaluation have been revised in accordance with the DORA declaration, to be more qualitative and to take into account all facets of the researcher's profession.

Science et société

The relationship between science and society is now recognized as an integral dimension of scientific activity. The project will develop this dimension in synergy with all the partners. The resulting research work will contribute to informing public decision-making. Participatory science initiatives may be initiated with actors of the socio-economic and cultural ecosystem of the project.

Indicateurs

The activity will be evaluated on the basis of scientific production (publications, software, patents, etc.), on institutional and private partnerships formalized by contracts, on international influence, on the valorization of work towards multidisciplinary scientific communities, on innovation and its transfer to society and on scientific dissemination to non-specialist audiences.

Modalités d'organisation des auditions

Seul(e)s seront convoqué(e)s aux auditions les candidat(e)s sélectionné(e)s sur dossier par la commission de sélection