Intitulé de l'offre : Insect-born pathogens M/F (H/F)
Acronyme : APVI
Référence : CPJ-2023-035
Nombre de Postes : 1
Site(s) concerné(s) : Strasbourg
Région(s) académique(s) : Grand Est
Etablissement(s) partenaire(s) envisagé(s) : Université de Strasbourg
Code(s) établissement(s) : UPR9002, UPR9022
Date de publication : jeudi 16 mars 2023
Type de contrat : Chaire de professeur Junior
Durée du contrat : 5 ans
Date d'embauche prévue : 1 juillet 2023
Quotité de travail : Temps complet
Rémunération : Annual salary from 54 600 Euros to 57 800 Euros depending on professional experience
Thématique scientifique : Immunology
Mots clés : Host-vector-pathogen interaction, virus, parasites, mechanisms of restriction
Section(s) CN : Host-pathogen relationship, immunology, inflammation
Titulaire d’un doctorat ou diplôme équivalent ou justifiant de titres et travaux scientifiques jugés équivalents par l’instance compétente de l’établissement. Il n’y a aucune condition d’âge ou de nationalité pour candidater. Tous les emplois CNRS sont accessibles aux personnes en situation de handicap en bénéficiant d’aménagement d’épreuves rendus nécessaires par la nature du handicap
The COVID19 pandemic has highlighted the importance of developing fundamental and translational research in infectiology. At the national (PEPR MIE and Prezode) and European levels, significant investments have been made to support the strategic preparedness for the emergence of new infectious agents with pandemic risk. The emergence or re-emergence of pathogens and the intensification of vector-borne diseases are also at the heart of the priority thematic orientations of the CNRS's 2019-2023 contract of objectives and performance and of the Health-Environment challenge of the CNRS COP21.
The CNRS has built an insectarium linked to the Strasbourg Institute of Molecular and Cellular Biology (IBMC). This insectarium, inaugurated in 2018 and labeled as an IBISA platform in 2020, is equipped with several BSL3 containment areas for the breeding of mosquitoes infected with pathogenic viruses or parasites and the manipulation of these pathogens. In this context, the junior professorship will be targeted on 3 units of the IBMC, the l’UPR9022, l’UPR9002 et l’UPR3572 already involved in this type of research.
Stratégie du laboratoire d'accueil
IBMC is recognized, at the national and international level, for its work on innate immunity in Drosophila (Jules Hoffman, Nobel Prize in Physiology and Medicine in 2011, CNRS Gold Medal 2011). For several years, IBMC has been seeking to broaden its research themes on insect immunity, particularly in insect vectors of viruses or pathogenic parasites. This strategy takes full advantage of the insectarium physically linked to the IBMC. This insectarium, which was awarded the IBISA platform label in 2020, is equipped with 8 mosquito breeding chambers of BSL3 containment, allowing the study of viruses and parasites that are pathogenic for humans, as well as BSL3 laboratories allowing the manipulation of these viruses. The research teams of UPR9022 (M3I, J.L. Imler) and UPR 9002 (RNA, P. Romby) of IBMC have developed a unique expertise in Europe on mosquito gene editing as well as a great expertise on the regulation of gene expression in viruses allowing to study in details the interactions between the host vector and arboviruses or parasites. In continuity, the UPR 3572 (I2CT, H. Dumortier) has developed human skin organoid models to study the response following infection by these pathogen vector mosquitoes.
In order to improve its international visibility in this extremely strategic and fast-growing thematic field, INSB wishes to increase the number of teams working on insect vectorized pathogens by targeting a junior professorship at UPR9022 (M3I, J.L. Imler), UPR 9002 (ARN, P. Romby) and UPR 3572 (I2CT, H. Dumortier).
UPR9022 and UPR9002 are members of the NetRNA labex (2021-2028) and part of the IMCBio Interdisciplinary Thematic Institute which includes a Graduate School as well as the Franco-German University, UFA.
UPR9022 has developed a partnership with the Chinese company INFINITUS, which has resulted in the establishment in China of research laboratories led by UPR9022 researchers. UPR9002 has developed several international partnerships (6International project and 2 ANR-DFG), obtained 3 Marie Curie contracts and 2 ERC.
Répertoire national des structures de recherche (RNSR) du laboratoire d'accueil
Résumé du projet scientifique
Anopheles and Aedes mosquitoes are vectors of parasites responsible for malaria, various pathogenic viruses (Chikungunya, Zika, Dengue, yellow fever ..) and some ticks are vectors of pathogenic bacteria (Y. Pestis). The CNRS has major assets to develop integrated research on these different pathogens at risk of epidemic or pandemic in times of global warming.
The research teams of UPR9022 (M3I, J.L. Imler) and UPR 9002 (RNA, P. Romby) at IBMC have developed a unique expertise in Europe on mosquito gene editing as well as a great expertise on the regulation of gene expression in viruses or bacteria allowing to study in detail the interactions between the host vector and these pathogens. These studies will allow a better understanding of the fundamental mechanisms of virulence evolution and co-evolution of the host-vector and the pathogen in order to develop relevant therapeutic approaches by targeting the vector. In parallel, the UPR 3572 (I2CT, H. Dumortier) studies the pathophysiology of these infections in humans and the immune response to these pathogens in order to open new therapeutic approaches.
Résumé du projet d'enseignement
The project will be integrated into the teaching of the University of Strasbourg, within the teaching teams in charge of immunology, cell biology and evolution.
- Total financé (dont package ANR) : 200 k€
- Total du projet : 200 k€
Scientific results will be disseminated through world-class scientific productions (publications, software, patents, etc.). In addition, the project will implement a communication towards various targets such as scientific communities, media, decision-makers, general public, schools, etc., with an adapted calendar. Specific tools could be developed such as websites, newsletters, meetings, international symposia, summer schools and conferences.
The CNRS is developing a strong policy in favour of open science. Open science consists of making research results "as accessible as possible and as closed as necessary". As such, the CNRS aims to make 100% of the texts of publications resulting from the work of its units accessible, in particular through deposit in HAL. The data produced must also be made available and reusable, unless there are specific restrictions. In addition, the guiding principles of individual evaluation have been revised in accordance with the DORA declaration, making them more qualitative and taking into account all facets of the researcher's job.
Science et société
The relationship between science and society is now recognised as an integral dimension of scientific activity. The project will develop this dimension in synergy with all the partners. The resulting research work will help to inform public decision-making. Participatory science initiatives may be initiated with actors from the project's socio-economic and cultural ecosystem.
The activity will be evaluated in particular on the basis of scientific production (publications, software, patents, etc.), on institutional and private partnerships formalised by contracts, on international influence, on the promotion of work to multidisciplinary scientific communities, on innovation and its transfer to society and on scientific dissemination to non-specialist audiences.
Modalités d'organisation des auditions
Seul(e)s seront convoqué(e)s aux auditions les candidat(e)s sélectionné(e)s sur dossier par la commission de sélection