Intitulé de l'offre : Inflammation and therapeutic targets M/F (H/F)
Acronyme : INFLATHERA
Référence : CPJ-2023-034
Nombre de Postes : 1
Site(s) concerné(s) : Montpellier, Toulouse
Région(s) académique(s) : Occitanie
Etablissement(s) partenaire(s) envisagé(s) : Université Montpellier, Université Toulouse
Code(s) établissement(s) : UMR5089, UMR5203
Date de publication : jeudi 16 mars 2023
Type de contrat : Chaire de professeur Junior
Durée du contrat : 5 ans
Date d'embauche prévue : 1 juillet 2023
Quotité de travail : Temps complet
Rémunération : Annual salary from 54 600 Euros to 57 800 Euros depending on professional experience
Thématique scientifique : Pharmacology, Physiopathology
Mots clés : inflammation, multi-scale communications, pharmacology, anti-inflammatory molecules
Section(s) CN : Pharmacology, bio-engineering, imaging, biotechnology
Titulaire d’un doctorat ou diplôme équivalent ou justifiant de titres et travaux scientifiques jugés équivalents par l’instance compétente de l’établissement. Il n’y a aucune condition d’âge ou de nationalité pour candidater. Tous les emplois CNRS sont accessibles aux personnes en situation de handicap en bénéficiant d’aménagement d’épreuves rendus nécessaires par la nature du handicap
The proposed subject of research is part of the “Living” thematic priority and the “Health and environment” societal challenge of the CNRS objectives and performance contract. The globalization of health risks as well as the importance of interactions between ecosystems and humans are involved in the evolution and emergence of pathogens and the determinism of chronic diseases. Changes in living conditions lead to an increase in chronic pathologies causing diseases with a poor prognosis (as cancer) and the appearance of communicable diseases. These pathologies are constantly increasing and have very serious human and societal consequences. Beyond the discovery/characterization of new pathogens or the observation of the re-emergence of known pathogens, a multi-scale vision of the living being is necessary to understand their impact on the organs particularly targeted and to propose therapeutic alternatives. Inflammation is a normal immune process at the heart of an organism's response to external or internal agents, but its deregulation can lead to many pathologies. Inflammatory processes are complex in a given tissue and also subject to inter-organ regulations (brain-gut/microbiota). The recruitment of a young researcher on a theme relating to the understanding of tissue or inter-organ inflammatory mechanisms to highlight their susceptibilities will allow significant progress in the definition of innovative therapeutic molecules. Interdisciplinarity is one of the strengths of the CNRS particularly represented in section 28 of the INSB. The project will be part of a global approach that will focus on the fundamental understanding of the mechanisms of inflammation regulation, the proposal of new therapeutic targets and relevant models for the possible screening of drug candidate molecules. Eventually, it will be able to rely on an interface with structural biology and biological chemistry to optimize these molecules. It will rely on major national CNRS infrastructures (FBI, ProFi, France Genomique).
Stratégie du laboratoire d'accueil
The Institute of Pharmacology and Structural Biology (IPBS) is one of the most advanced and innovative French centers in the field of characterization, targeting and treatment of pathological inflammation associated with diseases. The IPBS is developing a comprehensive research program that focuses on the fundamental understanding of the regulatory mechanisms of inflammation (immunology and pathophysiology), molecular screening, analysis and structural characterization of compounds, drug candidates and target/compound complexes, biological chemistry and pharmacology (in collaboration with several chemistry laboratories), as well as preclinical development and personalized medicine through animal models and the development of patient organoids from various affected tissues.
The Institute of Functional Genomics (IFG) is a multidisciplinary research center that is developing a project focused on the functional genomics of physiological and pathological cellular communications in the fields of neurobiology, endocrinology, oncology and cardiology. This project is developed through a multi-scale strategy 'from the molecule to the systems' combining structural, biochemical, genetic, epigenetic, omics, physiological and behavioral studies. An important effort is made to develop single-cell studies through multiple dimensions and multi-omics approaches, necessary to address the complexity of life. It is a multidisciplinary institute composed of two departments, "Physiology and Cancer", and "Neurosciences", and which also carries the GDR "Microglia and Neuroinflammation". The molecules and cells of inflammation are at the center of the bidirectional communication of the intestine-brain axis.
IPBS participates in many research networks in the European Commission's framework programs, from the Fifth Framework Program for Research, Technological Development and Demonstration Activities to Horizon Europe. The IPBS has a large experience in MSCA actions. It currently hosts one postdoctoral fellow (incoming fellowship, IF) and two PhD students as a partner in a doctoral network (DN). It hosted 5 postdoc fellows and coordinated 1 ITN network between 2014 and 2020. Numerous intra-European bilateral actions allow IPBS to train many Erasmus+ graduate/post-graduate students and 2 emerging international PI-to-PI actions with the Netherlands and Germany have already borne fruit. A long-term collaboration involving the Institute of Oncology of Ljubljana and the University of Primorska (Slovenia) in an associated European laboratory has been particularly remarkable. In addition, some IPBS teams are or have been members of European cross-border cooperation programs (POCTEFA). Currently, the IPBS hosts more than 60 PhD students of 10 different nationalities.
The IGF is a partner of European ITN networks (ITN ONCORNET and ONCORNET 2.0). The IGF regularly welcomes foreign PhD students and postdocs in the framework of international collaborations. For example, the IGF regularly receives students from the Huazhong University of Science and Technology in Wuhan (China), in the framework of a Franco-Chinese laboratory associating the IGF and this university, as well as Indian students (Cefipra funding, such as Raman-Charpak scholarships) in the framework of partnerships with various research institutes.
Répertoire national des structures de recherche (RNSR) du laboratoire d'accueil
Résumé du projet scientifique
Inflammation is a normal, regulated immune process that responds to external (such as pathogens or allergens) and internal (such as trauma and tissue damage) danger signals and contributes to tissue control and repair. When inflammation is dysregulated and self-perpetuating, it becomes chronic and can lead to many diseases. Inflammatory molecules and cells are also at the center of the bidirectional communication of the gut-brain axis (role of the microbiota). Understanding the cellular and molecular modalities of the deregulation of inflammation specific to each pathology is a crucial issue that holds the promise of characterizing new therapeutic targets for diseases whose prevalence is increasing rapidly. The CNRS wishes to recruit a young high-level scientist able to propose and develop a fundamental research project on the mechanisms of inflammation including multi-scale approaches (intercellular and inter-tissue communications) that could lead to new therapeutic perspectives for infectious diseases or the tumor microenvironment or chronic neurological pathologies.
Résumé du projet d'enseignement
The teaching project will be modulated according to the universities to which it is attached and must be integrated into the curricula developed with the teaching team concerned.
- Total financé (dont package ANR) : 200 k€
- Total du projet : 200 k€
Scientific results will be disseminated through world-class scientific productions (publications, software, patents, etc.). In addition, the project will implement a communication towards various targets such as scientific communities, media, decision-makers, general public, schools, etc., with an adapted calendar. Specific tools could be developed such as websites, newsletters, meetings, international symposia, summer schools and conferences.
The CNRS is developing a strong policy in favour of open science. Open science consists of making research results "as accessible as possible and as closed as necessary". As such, the CNRS aims to make 100% of the texts of publications resulting from the work of its units accessible, in particular through deposit in HAL. The data produced must also be made available and reusable, unless there are specific restrictions. In addition, the guiding principles of individual evaluation have been revised in accordance with the DORA declaration, making them more qualitative and taking into account all facets of the researcher's job.
Science et société
The relationship between science and society is now recognised as an integral dimension of scientific activity. The project will develop this dimension in synergy with all the partners. The resulting research work will help to inform public decision-making. Participatory science initiatives may be initiated with actors from the project's socio-economic and cultural ecosystem.
The activity will be evaluated in particular on the basis of scientific production (publications, software, patents, etc.), on institutional and private partnerships formalised by contracts, on international influence, on the promotion of work to multidisciplinary scientific communities, on innovation and its transfer to society and on scientific dissemination to non-specialist audiences.
Modalités d'organisation des auditions
Seul(e)s seront convoqué(e)s aux auditions les candidat(e)s sélectionné(e)s sur dossier par la commission de sélection