Reference : UPR9080-FABSTE-004
Workplace : PARIS 05
Date of publication : Thursday, November 24, 2022
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 February 2023
Proportion of work : Full time
Remuneration : 2889,51€
Desired level of education : PhD
Experience required : 1 to 4 years
A post-doc position is available starting from February 2023. The candidate will work in the group of Dr. Fabio Sterpone in Paris, in the Laboratoire de Biochimie Théorique at the Institut de Biologie Physico-Chimique (http://www-lbt.ibpc.fr/); the research will focus on the study of functional motions in the protein family of malate and lactate dehydrogenases by applying computational methodologies. The investigation will support NMR measurements and biochemical essays done by collaborators.
The research aims at individuating the functional modes in key representative members of the malate/lactate dehydrogenase protein family with the ultimate goal to single out the molecular basis at the origin of different functional regulations (allosteric vs non-allosteric enzymes). The study will also be extended to ancestral members of the family individuated via phylogenetic reconstruction. Further details and related publications can be found at: https://sites.google.com/site/sterponefabio/
The successful candidate must hold a PhD in Chemistry/Biophysics or related fields with a strong background in physical-chemistry/biophysics/statistical mechanics/bioinformatics. An extensive expertise in computer simulations of biomolecules and analysis of large-scale protein conformational changes is required. Proficiency in programming skills (Python) for post-processing are also highly desirable.
The contract is offered for 24 months. The position will be funded by the ANR. The exact salary will depend on the candidate's experience as evaluated by the French Centre National de la Recherche (CNRS) salary grid.
The Laboratoire de Biochimie Théorique is an internationally recognized laboratory with the mission of developing and applying computational methodologies to solve biological relevant problems. The members are active in the fields of docking, atomistic and coarse-grained simulations tackling problems as protein/protein and protein/DNA interactions, dynamics and function of membrane proteins, protein folding and aggregation.
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