Faites connaître cette offre !
Reference : UPR9022-VALWOL-002
Workplace : STRASBOURG
Date of publication : Monday, December 02, 2019
Type of Contract : FTC Scientist
Contract Period : 36 months
Expected date of employment : 1 February 2020
Proportion of work : Full time
Remuneration : from 2643,22 euros gross monthly according to experience.
Desired level of education : PhD
Experience required : 5 to 10 years
Postdoctoral position (male/female), three years, possible extension. Innate immunity, studies on the model organism Drosophila, possible extension later to mouse model. The project will investigate the defense reactions of Drosophila to oncogenic cells in a well established experimental system. Drosophila is devoid of adaptive immunity and the defenses therefore depend only on innate immunity
Characterization of innate immune receptors involved in the response to oncogenic cells, of the pathways activated and the effector molecules. Combination of genetic methods, of transgenesis experiments, of deep sequencing (organism and reactive cells), mass spectrometry, gene knock-out (CRISPR-Cas 9) and rescue experiments. All modern equipment available in the host institution. Intralaboratory collaboration with two full-time researchers, scientific program developed and financed in the frame of an established collaboration between CNRS and the Sino French Hoffmann Institute (SFHI) at Guangzhou Medical University (GMU).
First class knowledge in molecular and cellular aspects of innate immunity, transgenesis, gene knock-out with modern approaches, deep sequencing, bioinformatics. Fluent in English.
The program is part of a long-standing effort to establish the genetic, cellular and molecular bases of innate immune defenses in the model organism Drosophila. Previous studies from the lab focused on antibacterial/fungal defenses and were recognized by the Nobel Prize in 2011. The present project is centered on the reactions against oncogenic cells in an experimental system which is now well established. Studies will be performed in a small well supported group headed by Pr Jules Hoffmann (J.Hoffmann@unistra.fr) and comprises 2 permanent researchers, one technician and one secretary and is integrated into the CNRS Research Unit 9022 headed by Pr Imler (50 persons) It is associated with the Sino-French Hoffmann Institute, director Pr Renjie Jiao, of Guangzhou Medical University.
Constraints and risks
No specific risks others than those associated with the classical experiments of cellular and molecular biology. Optional : regular visits (2 or 3/year) to SFHI in Guangzhou.
We talk about it on Twitter!