Postdoctoral researcher in bacterial RNA structural and molecular biology (M/F)
New
- Researcher in FTC
- 13 mounth
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Architecture et Réactivité de l'ARN
Contract Type
Researcher in FTC
Working hHours
Full Time
Workplace
67084 STRASBOURG
Contract Duration
13 mounth
Date of Hire
01/04/2026
Remuneration
3071,50€ gross
Apply Application Deadline : 16 March 2026 23:59
Job Description
Missions
The postdoctoral researcher will join Stefano Marzi's team at CNRS UPR9002 (Strasbourg) within the ANR SatRNAsPG project, focused on structural and functional analysis of FemXAB–tRNAsGly–lipid II complexes involved in peptidoglycan synthesis and methicillin resistance in Staphylococcus aureus.
The candidate will work under the direct supervision of the project coordinator and contribute to an interdisciplinary program combining RNA biology, biochemistry, biophysics, and bacterial genetics.
Activity
Main activities will include:
Purification of native S. aureus tRNAs and analysis of RNA modifications (LC-MS/MS, RNA-seq approaches)
Purification of Fem proteins and assembly of ribonucleoprotein complexes
Biophysical characterization (SEC, DLS, MALS, SAXS, native MS)
RNA–protein interaction assays (EMSA, DRaCALA, RIP)
S. aureus genetics (mutant strains, tagged proteins) and phenotypic analyses
Investigation of crosstalk between peptidoglycan synthesis and translation, notably via the shared glycyl-tRNA synthetase (GlyRS)
Participation in structural studies (cryo-EM, X-ray in collaboration)
Dissemination of results through publications and presentations
Your Profil
Skills
- Recent PhD in molecular biology, microbiology, biochemistry, or related fields
- Strong background in protein and/or RNA biochemistry
- Interest in structural and functional biology
- Experience in RNA biology, RNA modifications, or biophysics is a plus
- Good command of written and spoken English (French not required)
- Ability to work independently and collaboratively
- Strong analytical, organizational, and scientific writing skills
- Experience in bacterial translation regulation is a plus
Your Work Environment
CNRS UPR9002 is a research unit in Strasbourg dedicated to RNA regulation in diverse organisms, including bacteria, viruses, and eukaryotes.
The postdoctoral researcher will join a group specifically focused on pathogenic bacteria, combining RNA biology, biochemistry, and structural approaches to investigate molecular mechanisms of bacterial adaptation and virulence.
The position is part of a collaborative national ANR project with several partners and provides access to state-of-the-art facilities (cryo-EM, mass spectrometry, sequencing platforms).
The site is easily accessible by public transport. CNRS benefits include subsidized meals, partial transport reimbursement, and paid leave.
Compensation and benefits
Compensation
3071,50€ gross
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UPR9002-STEMAR-003 |
|---|---|
| CN Section(s) / Research Area | Molecular and structural biology, biochemistry |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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