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Reference : UPR8241-EMIMAT-002
Workplace : TOULOUSE
Date of publication : Friday, November 12, 2021
Type of Contract : FTC Technical / Administrative
Contract Period : 13 months
Expected date of employment : 10 January 2022
Proportion of work : Full time
Remuneration : 2109-2226€ monthly gross salary depending on experiences
Desired level of education : 3-year university degree
Experience required : 1 to 4 years
Peptide synthesis (solution, solid phase)
Characterization of peptide-copper catalysts
Determination of catalytic activity
-Synthesis of peptide sequences of 2 to 40 amino acids in solution or on solid phase
-Determination of the catalytic activity of copper-peptide complexes on a key reaction (analysis of the reaction crude by NMR, purification of products, determination of the reaction yield, determination of the enantiomeric excess by chiral chromatography)
-Characterization of catalysts by UV-vis, fluorescence, EPR, NMR spectroscopy
-Expertise in peptide synthesis techniques, in solution and on an automat-assisted support, in fmoc strategy
-Expertise in purification techniques (HPLC) and characterization of peptides (NMR, ESI-MS)
-Strong skills in organic synthesis (reaction monitoring, product purification). Experience in catalysis is desirable.
-Strong skills in physical chemistry (UV-visible and fluorescence spectroscopy). Experience in chiral HPLC is desirable.
-Competences with general computer tools (Office) and specific to the field (scifinder, NMR processing software, chemdraw,...)
-Organization and time management for the realization of experiments within defined deadlines
-Ability to work in a team
-Ability to present the results obtained, orally and by writing reports, in French and English.
The work will be mainly performed at the CNRS Coordination Chemistry Laboratory (UPR 8241) in the team "Alzheimer and Amyloids, Bio-inorganic Chemistry" directed by Dr. Christelle Hureau. The objective is to develop copper-peptide catalysts for organic synthesis (C-C bond formation) whose state (in solution or aggregated) can be controlled.
The research work of the group is focused on the study of metal cation-peptide interactions, including the role of metal ions in the aggregation of "amyloid" peptides involved in Alzheimer's disease.
Constraints and risks
Handling of chemicals.
The candidate is requested to send a CV and a letter explaining his/her motivations to join the group, including (if possible) the contact details of one or two referees.
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