Missions

The MILE and ELIA teams at LAAS are looking for a post-doctoral researcher to take charge of instrumentation activities for organ-on-a-chip developments in the context of the targeted ENVie project of the PEPR MED-OOC programme. In this multi-partner project, LAAS is responsible for developing new generations of organs-on-a-chip dedicated to the study of digestive pathologies (colon or pancreas). These systems will be instrumented with microfluidic technologies for controlling interstitial flow and characterising the poromechanical properties of tissues. It is on this aspect, at the interface between manufacturing and operational implementation of the lab-on-a-chip, that the candidate will work in conjunction with the laboratory's technology and instrumentation platforms.

Activities

The candidate will design organ-on-a-chip devices, integrating them with electrical and/or pneumatic instrumentation. The organs-on-a-chip will then be manufactured either from cultured lines seeded in matrices, with the ultimate aim of using patient samples directly, such as isolated cells, organoids or tissue explants. The organs-on-a-chip will then be characterised over time in order to monitor their development, either by optical microscopy or using more specific technologies developed at LAAS. It should be noted that the candidate will be involved in a wide range of activities, from manufacturing devices to writing experiment reports and setting up experimental benches. He/she will enjoy considerable autonomy and organisational freedom within the framework of the targeted ENVie programme.

Skills

Expertise in microfluidic instrumentation technologies,
Expertise in additive manufacturing technologies (3D printing, laser writing, etc.)
Mastery of cell culture; knowledge of biomaterials and culture matrices would be appreciated.
Proficiency in optical microscopy techniques for cell characterisation,
Fluency in written and spoken technical English,
Intellectual curiosity and willingness to learn,
Ability to interpret/critique measurements.

Work Context

As part of the PEPR MED-OOC programme, LAAS is responsible for the manufacturing technologies for a new generation of organs-on-a-chip including patient cells. These developments will be carried out in a collaborative context involving several regional laboratories, but also in interaction with the other targeted PEPR projects. The work in the LAAS environment will be based on the various manufacturing technology platforms, from the nanometric scale to centimetric devices. The position is located in a sector covered by the ZRR (Zone à Régime Restrictif), and therefore requires, in accordance with the regulations, that your arrival be authorised by the competent authority of the MESR.

The position is located in a sector under the protection of scientific and technical potential (PPST), and therefore requires, in accordance with the regulations, that your arrival is authorized by the competent authority of the MESR.

Constraints and risks

No special mention.