Missions

The main objectives of the researcher will be:
- Synthesize ligands for metal complexation
Study the properties of thermodynamic stability and kinetic inertness of complexes
- Study the relaxation properties and MRI effectiveness of the complexes
Evaluate their activity on cellular and mouse models.

Activités

- Implementation of experimental plans to carry out this project, in consultation with the PI
- Synthesis of new ligands
Complexation of ligands, identification of suitable conditions
- Study of the physicochemical properties of the complexes by NMR, relaxometry, potentiometry and UV-visible spectroscopy
Cell studies and participation in preclinical evaluation.
- Participation in discussions on project progress with other participants, members of the group or collaborators
- Analysis and formatting of results
- Writing publications
- Presentations of the results obtained at conferences

Compétences

- Experience in organic synthesis of ligands for metal complexation
- Experience in NMR
- Experience in physico-chemistry and coordination chemistry, in cellular work and histology
- Ability to communicate, organize, work in a team but also independently
- Rigor and motivation
- Experience to ensure the traceability of processed data and the reproducibility of the analyzes carried out
- Ability to disseminate scientific results in writing and orally
- Ability to write scientific articles
Experience in the field of MRI contrast agents would be a plus.

Contexte de travail

At the CNRS, within the Center for Molecular Biophysics (UPR4301) based in Orléans, a researcher position is open in the “Metal complexes and MRI” group (http://cbm.cnrs-orleans.fr/). CBM (UPR 4301) is a CNRS research unit with 150 staff working in synergy at the interface between physics, biology and chemistry. The researcher will be part of the "Metal complexes and MRI" group and will be supervised by the PI of the project. He / She will interact with the other members of the group (4 CNRS researchers, 1 lecturer, 2 research engineers, 1 study engineer and 4 PhD students a,d 2 post docs). He / She will have access to state of the art equipment of the team and of the NMR and MRI platforms in CBM. The selected candidate will participate in a project funded by the National Research Agency whose objective is to design and characterize contrast agents for Magnetic Resonance Imaging.