Informations générales
Intitulé de l'offre : Cellular and molecular control of lymphoid tissue formation (M/F) (H/F)
Référence : UPR3572-GEOMUE-007
Nombre de Postes : 1
Lieu de travail : STRASBOURG
Date de publication : mercredi 7 mai 2025
Type de contrat : Chercheur en contrat CDD
Durée du contrat : 12 mois
Date d'embauche prévue : 16 juin 2025
Quotité de travail : Complet
Rémunération : Between 3 021,50 to 3 451,51 EUR bruts mensuel, varies with experience
Niveau d'études souhaité : Doctorat
Expérience souhaitée : Indifférent
Section(s) CN : 27 - Relation hôte-pathogène, immunologie, inflammation
Missions
The project investigates the cellular and molecular mechanisms underlying the development of lymphoid tissues, such as the lymph node. We have previously shown that RANK/TNFRSF11a expression by lymphatic endothelial cells is required for the sinusoidal macrophage niche in the lymph node (10.1016/j.immuni.2019.05.008) and spleen (10.1073/pnas.2108540119). The researcher will now extend these studies in newly developed mouse models to explore the molecular and cellular interactome involving lymphatic endothelial cells, macrophages and mesenchymal stromal cells in lymph node development. In addition, the candidate (M/F) will transpose these results to humans, using mesenchymal cells and lymphocytes obtained from various human tissues to reconstruct lymphoid structures in cell culture.
Activités
The activity of the candidate (M/F) is focused on the analysis of murine models and human cell cultures, generating immunofluorescence and flow cytometry data as well as transcriptomic data. Functional tests will include immune cell activation, cell proliferation and differentiation.
Compétences
The candidate (M/F) must have solid experience in
- flow cytometry
- immunofluorescence on tissue sections
- image analysis
- cell culture,
- and a solid theoretical background in immunology.
The candidate (M/F) will be dynamic, responsive and enjoy working in a team. You have good communication skills and are available for frequent travel and atypical working hours. Oral and written expression in English (C1) and French (C1) is required (international team/collaboration, work with study protocols written in French and English).
Contexte de travail
The post-doctoral fellow (M/F) will join Dr. Christopher Mueller's team “Immune-microenvironment interactions in health and disease”, is under his supervision and includes direct interaction with PhD students and engineers. The team currently comprises 2 researchers, 1 post-doctoral researcher, 1 technician, 8 PhD students and 2 master's students.
The advantages of the job include its location close to the city center, an administrative restaurant, nearby public transport and partial employer benefits.
The team is well connected internationally and is part of the URI group and the EURIdoc program. It has many links with the industrial sector.
Contraintes et risques
The constraints of the position may include shifting hours and weekend work.