Missions

Plant–pathogen interactions are complex processes that involve profound molecular and physiological changes in both the host and the pathogen. An increasing body of evidence highlights the role of epigenetic mechanisms in plant defense against pathogens. Recently, we demonstrated that a bacterial virulence factor can trigger global alterations in DNA methylation, and similar changes to the plant methylome have been observed during bacterial infection. However, the lack of spatio-temporal resolution limits our understanding of the extent and functional significance of these chromatin modifications during infection.
As part of the EPIPAT ERC-funded research project, we are seeking a motivated, diligent and curious scientist to develop innovative tools and methods to investigate nuclear changes during bacterial infection, combining imaging approaches with omics analyses.

Activités

The successful candidate will work on bacterial infections in Arabidopsis, conducting a broad range of genetic and molecular analyses including PCR, qPCR, genetic crosses, and phenotypic assessments. They will perform standard molecular biology techniques such as cloning and RNA and DNA extraction, as well as carry out epigenomic and transcriptomic experiments to investigate how chromatin modifications influence plant defense. The role also involves classical and confocal microscopy of plant tissues, with an emphasis on developing imaging approaches specifically adapted to studying infected plants. In addition, the candidate will help establish FACS protocols, generate transgenic lines, and integrate diverse datasets to advance the objectives of the project. They will critically analyze and interpret results, situate findings within the broader scientific literature, and communicate their work effectively through written reports and oral presentations in English. The position may also include the opportunity to supervise and mentor students involved in related aspects of the research.

Compétences

We are looking for motivated and curious candidates with team spirit, eager to learn and to explore new approaches. Candidates should be able to analyze results critically yet constructively, demonstrate solid problem-solving skills, and manage their projects with a high degree of autonomy. Applicants should hold a PhD (or possibly a Master's degree) in in plant biology, molecular biology, genetics, or a related field. Experience with Arabidopsis growth, genetics, and standard molecular biology techniques is required. Candidates should also have hands-on experience with imaging techniques, ideally confocal microscopy; experience with FACS is an additional asset. Prior work in plant epigenetics, small RNAs, or plant reproduction is welcome but not mandatory. Excellent communication and writing skills in English are essential, and candidates must be able to independently present their results both orally and in written form in English (minimum B2 level).

Contexte de travail

The work will be performed in a dynamic and supportive research environment at the Institut de Biologie Moléculaire des Plantes (IBMP) in Strasbourg, providing access to state-of-the-art facilities in imaging, genomics, and plant molecular biology. As part of an ERC-funded project, this position offers the opportunity to tackle cutting-edge questions at the intersection of epigenetics and plant–pathogen interactions. The successful candidate will join the epigenetic and plant reproduction team (www.jullienlab.com), a collaborative and international team committed to both scientific excellence and personal growth. He/She will benefit from tailored mentoring, opportunities to develop new technical and analytical skills, and support to strengthen their scientific network and publication record.

Contraintes et risques

• Possible travel for conferences or collaborations.
• Standard laboratory risks associated with molecular biology, including exposure to chemical products, biological agents, thermal environments, and extended work at computer screens.