Missions

The candidate will develop advanced cultivation, extraction and analytical methods to evaluate the bioremediation potential of filamentous fungi. He or she will be responsible for the evaluation of pre-selected fungal strains to degrade hydrocarbons, the analysis of specialized metabolites produced under pollution conditions, and the development of pilot-scale cultivation.

Activités

-Develop cultivation and extraction methods adapted to filamentous fungi for the production of surfactants
-Analyze and characterize all the specialized metabolites produced by mastering spectrometric and spectroscopic analysis methods
-Develop preliminary tests to evaluate the bioremediation potential of filamentous fungi
-Optimize culture conditions for pilot scale-up
-Present and promote the results obtained

Compétences

General theoretical or disciplinary knowledge: Expertise in natural product chemistry, good knowledge of microbiology.
Operational skills:
- Proficiency in natural product analysis and separation techniques (HPLC, flash chromatography, SPE)
- Proficiency in liquid chromatography (reverse-phase chromatography) and mass spectrometry techniques
- Proficiency in spectrometric and spectroscopic techniques for structural elucidation
- Proficiency in computer tools for processing LC, LC-MS, and NMR data
- Proficiency in computer tools for processing LC-MS/MS data;
- Knowledge of applied microbiology would be an asset
- Communicate and ensure scientific exchanges with project collaborators;
- Work in a team and collaboratively in a multidisciplinary context
- Master written and oral English (level B2 according to the Common European Framework of Reference for Languages) for the presentation of results at conferences and the writing of publications.

Contexte de travail

The Institute of Chemistry of Natural Substances is a CNRS Research Unit whose research focuses on chemistry and biology. It is part of the Université Paris-Saclay, which has brought together the research and teaching institutions of southern Paris since 2015. The ICSN is located on the Gif-sur-Yvette campus and has approximately 125 employees, including 76 permanent staff, spread across three buildings.
Within the Department of Natural Substances and Medicinal Chemistry, the recruited employee will join the "ICSN Pilot Unit" team. They will report to the team leader. The employee will work directly with all members of the team, as well as in collaboration with the partners of the ANR Mic GIVER project. This project aims to explore the bioremediation potential of microscopic fungi on four groups of pollutants of human activities: glyphosate, diesel, waxes and nitrate explosives.