Portal > Offres > Offre UPR2301-DIEGAU-002 - Post-doc H/F: Biologie structurale intégrative des cages protéiques et approches de glyco-conjugaison

Postdoctoral Position (M/F): Integrative Structural Biology of Protein Cages and Glyco-Conjugation Approaches

This offer is available in the following languages:
- Français-- Anglais
Application Deadline : 02 February 2026 23:59:00 Paris time

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General information

Offer title : Postdoctoral Position (M/F): Integrative Structural Biology of Protein Cages and Glyco-Conjugation Approaches (H/F)
Reference : UPR2301-DIEGAU-002
Number of position : 1
Workplace : GIF SUR YVETTE
Date of publication : 12 January 2026
Type of Contract : Researcher in FTC
Contract Period : 18 months
Expected date of employment : 1 April 2026
Proportion of work : Full Time
Remuneration : Between 3 081,33 and 4 756,76 € gross per month, depending on experience.
Desired level of education : Doctorate
Experience required : Indifferent
Section(s) CN : 16 - Chemistry of and for life: design and properties of molecules of biological interest

Missions

• Study the structure and dynamics of protein cages using an integrative approach
• Develop glyco-conjugated derivatives of protein cages (via cysteine-exposed mutants) for biotechnological and therapeutic applications
• Coordinate interdisciplinary collaborations (protein production, sugar synthesis, structural analyses) and ensure data integration for unified interpretation
• Publish results in international journals and present advances at conferences (e.g., structural biology, nanobiotechnology)

Activities

• Production and purification of protein cages and their cargoes
• Structural and dynamic characterization: Integrated data analysis (computational modeling, correlation of NMR/EPR/EM/MS data) and scientific manuscript writing
• Project management: Experiment planning and coordination with partners

Skills

• PhD in structural biology, biochemistry, or biomolecular chemistry with proven expertise in NMR (solid-state or solution) and/or protein biophysics.
• Practical experience:
- Protein production/purification (bacterial systems, isotopic labeling).
- Complementary techniques: NMR, EPR, native mass spectrometry, cryo-EM, or molecular modeling (a plus).
• Autonomy and collaborative spirit: Ability to lead an interdisciplinary project and interact with teams of diverse expertise.
• Scientific English: Fluent level (writing articles, international presentations).

Work Context

• Host laboratory: Specialized team in integrative structural biology, with privileged access to:
- 600 MHz NMR spectrometer equipped with a dedicated 1.3 mm CPMAS probe.
- Platforms for cryo-EM, mass spectrometry, and molecular biology.
- Extensive collaborative network.
• Scientific environment: Project funded by EMERGENCE@INC 2026, with a focus on innovation and valorization.