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Portal > Offres > Offre UPR2301-CARVAN-001 - Chercheur/chercheuse (H/F) post-doctoral en modélisation moléculaire et algorithmique - caractérisation d'interfaces protéines-ligands à partir de données RMN

Post-doctoral Researcher (M/F) in molecular modeling and algorithmics - Characterization of protein-

This offer is available in the following languages:
Français - Anglais

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General information

Reference : UPR2301-CARVAN-001
Workplace : GIF SUR YVETTE
Date of publication : Monday, September 30, 2019
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 1 February 2020
Proportion of work : Full time
Remuneration : Between 25996€ and 37201€ net per year depending on research experience
Desired level of education : PhD
Experience required : Indifferent

Missions

- Develop computer tools and / or molecular modeling to precisely characterize protein / ligand interfaces without attribution of the protein from NMR data
- Test approaches developed from real data acquired on relevant therapeutic systems from the industrial partner and from the laboratory.

Activities

Main activities
- Computer programming
- Algorithmic problem solving
- Molecular modeling applied to proteins
- Analysis of NMR data
Secondary activity
- Perform NMR experiments to characterize proteins interactions with ligands

Skills

- Strong experience in molecular modeling
- Strong programming experience
- Competence in algorithmic
- Knowledge in NMR will be a plus
- Know how to work in a team

Work Context

Brief description of the issues and missions of the unit

The "Institut de Chimie des Substances Naturelles" (ICSN) is a chemistry institute engaged in fundamental research related to the valorization of natural products, combining its expertise in chemistry with biological studies and aimed mainly at improving human health and progress on the environment. ICSN combines unique expertise not only in all aspects of natural product research, but more broadly in a variety of areas ranging from methodology to organic synthesis and catalysis, medicinal chemistry, analytical chemistry and chemical biology, structural biology and biology. The ICSN associates complementary skills structured within its 4 research departments, namely: Natural substances and medicinal chemistry (SNCM), Exploratory chemistry in organic synthesis and catalysis (ChimEx), Chemical biology (ChemBiol) and Analytical and Structural Chemistry and Biology (ChimiBiSA). The missions of the ChimiBiSA department, to which the agent will belong, are: to identify the major problems in chemistry and biology in which the techniques that we master can bring key answers, develop new methodologies to bring the techniques that we master to new possibilities , promote and implement our techniques in the research of chemists and biologists of our environment. The ChimiBiSA department relies on exceptional equipment and expertise in molecular modeling, structural crystallography, mass spectrometry, nuclear magnetic resonance (NMR), molecular / cellular biology and various purification / analysis methods. In particular, ICSN's high-field NMR platform is part of the FRISBI (IBISA label) and IR-NMR (CNRS-INC) national infrastructures, and aims to implement the most recent experiments on state-of-the-art equipment for the local, national and international scientific community at the interface of chemistry and biology.

The researcher will work in collaboration with the research institute Servier, with whom the team of Biology and Structural Chemistry has a long-standing partnership.

Presentation of the unit: its location, its workforce, its research themes ...
The ICSN is a CNRS own research unit. His research projects focus on the chemistry of natural substances and on several ancillary domains particularly oriented to the chemistry-biology interface. The ICSN is part of the Paris Saclay University which brings together, since 2015, research and higher education institutions in southern Paris. The unit is located on the campus of Gif-Sur-Yvette, and has 81 permanent agents and 59 contract agents including 40 doctoral students, and welcomes about fifty trainees per year.
The agent will be located at ICSN Building 23B.

Hierarchic reattachment
The researcher will work in the "NMR, Biology and Structural Chemistry" team within the ChimiBiSA department of ICSN. Carine van Heijenoort is the coordinator of the department. The researcher will work under the responsibility of François Bontems, expert in molecular modeling and protein NMR, and Carine van Heijenoort, expert in protein NMR. He will also work in close collaboration with a researcher from Servier, and will have to report regularly on the progress of his research to the Servier researchers involved in the project.

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