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Portail > Offres > Offre UMR9198-PHIMIN-002 - (H/F) Post Doc :Ingénierie d'assemblages de protéines synthétiques, conception, production, applications

Design production and application of synthetic proteins assemblies

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : mardi 1 février 2022

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General information

Reference : UMR9198-PHIMIN-002
Workplace : ORSAY
Date of publication : Tuesday, January 11, 2022
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 March 2022
Proportion of work : Full time
Remuneration : Gross salary from 2743 to 3900 euros per month, based on previous experience
Desired level of education : PhD
Experience required : Indifferent

Missions

Our group has developed efficient methods to create new artificial proteins able to interact tightly and specifically with any predefined protein target. Our objective is now to design build and characterize new multi-protein assemblies from synthetic protein building blocks. These assemblies will be designed in view of a range of applications in structural biology, cell targeting , or scaffolding of metabolic pathways

Activities

- Design of assembly protein building blocks
- Recombinant protein expression
- Characterization of protein/protein interactions and assembly
- In collaboration, electron microscopy characterization of synthetic assemblies
- Design production and tests of synthetic cell targeting protein complexes

Skills

Practical experience in recombinant protein expression and protein biochemistry
Interest for structural biology (X ready crystallography and or electron microscopy)
Experience in collaborative project management
Interest for fundamental aspects of protein engineering as well as for biotech applications

Work Context

This post doc position covers two successive periods.
- A first one year contract mainly focused on collaborative project involving several group (protein design and engineering, electron microscopy, virology and microbiology) in the host institute (I2BC)
- If OK this first project will be followed be followed by an ANR funded two-years contract aiming at develop new self-assembling synthetic protein architecture called protein “Origamis” in relation with nanoscience applications

Cette première période, si favorable, sera prolongée par un projet de deux années, dont le financement est acquis, et portant sur la conception, la fonctionnalisation et la caractérisation d'assemblages protéiques « origami », c'est-à-dire d'architectures auto-assemblables élaborées à partir de protéines en relation avec les applications en nanosciences.

Constraints and risks

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