Reference : UMR9198-JULSOU-001
Nombre de Postes : 1
Workplace : SACLAY
Date of publication : Thursday, January 19, 2023
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 April 2023
Proportion of work : Full time
Remuneration : gross monthly salary between 2889.51€ and 4082.90€ depending on experience
Desired level of education : PhD
Experience required : 1 to 4 years
The interdisciplinary project aims to improve our understanding of the mutational processes at the origin of cancers. We seek to decipher the impact of transcription and DNA repair combined with mutagen exposure on mutational processes using a combination of genetic, genomic, microfluidic and computational approaches.
The candidate will participate in a collaborative project using the Saccharomyces cerevisiae yeast model to perform large-scale mutational experiments and identify the most mutagenic combinations of genetic background and mutagenic treatment. A novel microfluidics-based approach that we recently developed will be applied to strongly accelerate mutation accumulation experiments in yeast at the genomic scale. Thanks to the complementary expertise of the project partners, a computer analysis of these experimental data will help to understand the mechanisms underlying the mutational processes and the knowledge acquired in yeast will then be transferred to human cells.
The successful candidate should hold a PhD in molecular biology with a strong background in genetics and functional genomics. We are looking for highly motivated candidates with a strong interest in the field of transcription and DNA repair in eukaryotes with interdisciplinary approaches based on microfluidics. Previous experience in approaches using the yeast model and high-throughput DNA sequencing will be important. Good communication skills in English or French are required.
The Institut de Biologie Intégrative de la Cellule (I2BC) is a joint research unit (CNRS, CEA and the Paris-Saclay University). The institute is made up of 60 research teams divided into 5 departments and 14 high-level technological platforms. The position is in the "Genome transcriptional regulation" team in the "Genome Biology" department, in close collaboration with the Interdisciplinary Laboratory on Nanoscale and Supra Molecular Organization (LIONS, CEA/Saclay).
The team is located in the building 144 on the CEA site at Saclay, Gif-sur-Yvette.
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