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Portal > Offres > Offre UMR9198-CHROUL1-019 - CDD Post-doctorant - Chercheur (H/F) : Role des sites de contact membranaires entre le reticulum endoplasmique et les mitochondries dans le traffic lipidique et implication dans les maladies neurodegeneratifs

Postdoc in Cell Biology: Role of the endoplasmic reticulum-mitochondria membrane contact sites in li

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Français - Anglais

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General information

Reference : UMR9198-CHROUL1-019
Workplace : GIF SUR YVETTE
Date of publication : Thursday, September 26, 2019
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 December 2019
Proportion of work : Full time
Remuneration : Monthly gross salary between 2690 € and 3840 € according to experience
Desired level of education : PhD
Experience required : Indifferent

Missions

Characterization of new protein components of endoplasmic reticulum- mitochondria membrane contact sites involved in lipid trafficking, in physiological and pathological conditions (i.e. Alzheimer's disease cellular models).

Activities

- Autonomous conduct of a research project,
- Design and realization of microscopy (confocal and electronic microscopy) and biochemical techniques, including in situ (subcellular fractionation) and in vitro (protein purification, reconstitution of proteo-liposomes in vitro) experiments required for the project.
- Presentation of the results at group meetings and conferences
- Writing scientific articles resulting from the scientific activity and supervision of undergraduate students.

Skills

The candidate should hold a PhD degree, or equivalent research experience, in cell biology and/or biochemistry. He/she should have experience in mammalian cell culture and in multiple imaging approaches including confocal microscopy. Additional expertise in electron microscopy will be beneficial, but he/she can be trained. Experience in membrane reconstitution approaches in vitro (liposome preparation by extrusion, protein purification and reconstitution in vitro,..) is also welcomed. The candidate must be independent, well-organized, with excellent oral and written communication skills, and ability to work in a team. He/she should have the capacity to supervise undergraduate students. He/she should manage his/her own research and administrative activities, coordinate different aspects of the work to meet deadlines. He/she should carry out literature reviews and compile the results for publication in peer-reviewed journals, present papers and posters. He/she should carry out collaborative projects with colleagues in partner institutions, and actively participate in journal club and lab meetings.

Work Context

The post-doctorate will be held in the new team "Lipid Trafficking and Membrane Contact Sites" (https://www.i2bc.paris-saclay.fr/spip.php?article1271) at the Institute for Integrative Biology of the Cell (UMR 9198 I2BC, CNRS / CEA / University Paris-Sud).

The I2BC is a new research institute of Paris-Saclay University, on the CNRS campus in Gif-sur-Yvette. The I2BC hosts 69 research teams representing a total of 750 people. Research at I2BC covers a wide range of topics in genome biology, cell biology, microbiology, virology, biochemistry and structural biology.

The team is attached to the Department of Celullary Biology and studies the mechanisms of communication and exchange between various cell organelles through the non-vesicular pathway that takes place at membrane contact sites. In particular, we are interested in understanding the molecular basis of lipid and calcium exchanges, that are essential for cellular homeostasis and are affected in several disorders including neurodegenerative diseases.

Constraints and risks

There are no constraints. Biological and chemical risks

Additional Information

Interested applicants should send the application including a cover letter, curriculum vitae and contact information of three referees

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