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Reference : UMR9198-CHROUL1-012
Workplace : GIF SUR YVETTE
Date of publication : Monday, February 04, 2019
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 March 2019
Proportion of work : Full time
Remuneration : Salary between 2605 à 3615 € brutto per month according to experience
Desired level of education : PhD
Experience required : Indifferent
Study of the genetic basis of cellular and molecular mechanisms used by bacteriophages to infect the Gram-positive bacterium Bacillus subtilis.
Bacteriophage SPP1, like numerous eukaryotic viruses, establishes viral factories confined at specific locations of the host cell (J. Bacteriol. 193: 4893).
The project aims to pursue:
- the study of the bacterial cytoplasm spatial reorganization during bacteriophage infection
- the identification and caracterisation of viral proteins that hijack cellular functions and their bacterial targets. Infection at different stages of the B. subtilis cell cycle will be characterized (J. Virol. 89: 2875).
The approach is interdisciplinary, combining genetics, virus engineering and genome refactoring (e.g. Proc. Natl. Acad. Sci. USA 112: 7009), omics, and state of the art cell imaging techniques.
- the project is particularly suitable but not limited to candidates holding a PhD in bacterial/phage genetics, molecular biology or cell biology.
- experience in molecular biology, in bacteriology or in bacterial cell biology
- expertise in bacteriophage or in Bacillus manipulation is an asset
- knowledge of english language
The host team Bacteriophages of Gram-Positive Bacteria studies assembly of viral particles of tailed bacteriophages and infection of Gram-positive bacteria by these viruses (https://www.i2bc.paris-saclay.fr/spip.php?article580).
The team is associated to the Department of Virology at Institute of Integrated Biology of the Cell (http://www.i2bc.paris-saclay.fr/spip.php?article312) that provides a strong interdisciplinary environment for biological sciences research in the CNRS Campus of Gif-sur-Yvette (Paris region). The host Institute offers state of the art facilities for molecular biology, genomics, microbiology, advanced cell imaging, proteomics, and structural biology research.
The position is initially for 1 year, renewable.
To apply please submit your CV, a short research statement, together with the name and e-address of references before the 1st December 2018.
Starting date is after 1st January 2019.
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