Missions

Biomolecular condensates have recently emerged as fundamental in cell biology, complementing membrane-bound organelles in the organization of cellular functions. Biomolecular condensates are mesoscopic membrane-less organelles that allow the dynamic orchestration of biochemical reactions by restricting them to a confined space. Cytoplasmic RNA-protein (RNP) condensates are a class of biomolecular condensates, classically described as hubs for mRNA regulation. Most RNP condensates are composed of heterogeneous immiscible phases, but how this feature contributes to their biological functions remains largely unexplored. Using germ granules in Drosophila embryos, an outstanding model of RNP condensates, we recently demonstrated the functional compartmentalization of germ granules, translational repression and activation taking place in two distinct phases. The project will focus on dissecting the intricate relationships between RNP condensate architecture and functions. Using genetics, chemical approaches and an advanced system to generate artificial condensates, the candidate will address how mRNA translation contributes to germ granule biphasic architecture and biophysical properties.

Activities

- Drosophila genetics
- Molecular biology
- Advanced imaging (super-resolution, single-molecule imaging, FRAP)
- Oral presentation, participation to meetings, writing manuscripts

Skills

- Expertise in Drosophila genetics
- Expertise in RNA biology
- Strong expertise in imaging
- Capacity to work independently and with the team

Work Context

The Institute of Human Genetics provides a stimulating international research environment; it is fully endowed with state-of-the-art scientific equipment and has direct access to cutting-edge facilities.
The IGH is located on the Arnaud de Villeneuve campus, which is part of the Pro-Cycling Employer Programme.