(M/F) Research Engineer in Cell Culture and Molecular Biology, Haematology.
New
- IT in FTC
- 12 mounth
- BAC+3/4
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut de Génétique Humaine
Contract Type
IT in FTC
Working hHours
Full Time
Workplace
34396 MONTPELLIER
Contract Duration
12 mounth
Date of Hire
01/05/2026
Remuneration
from €2,521 gross per month, subject to adjustment based on professional experience in equivalent roles
Apply Application Deadline : 06 April 2026 23:59
Job Description
Missions
Plasma cells (PCs) represent the terminal stage of B‑cell differentiation. B cells are continuously produced throughout adult life and undergo various genetic rearrangements associated with immunoglobulin maturation, including VDJ recombination, class‑switch recombination (CSR), and somatic hypermutation (SHM). Secondary lymphoid organs can also harbor different oncogenic events which, depending on their mechanisms, may initiate oncogenic transformation leading to multiple myeloma (MM) or diffuse large B‑cell lymphoma (DLBCL). We have shown that PC generation can be modeled in vitro by recapitulating the steps associated with PC maturation in the different organs/tissues in vivo. In this project, we aim to build on our preliminary results and develop a CRISPR–Cas9 screen to explore the molecular events involved in tumorigenesis, with a focus on genomic instability and epigenetic deregulation. We will seek specific therapeutic vulnerabilities to target tumor cells. The results of this project should provide key insights for targeting the cellular progenitors of these diseases.
Activity
Cellular biology.
Molecular biology.
Screening.
Cell culture of primary samples.
Plasma cell differentiation.
Data analysis.
Your Profil
Skills
References and letters of recommendation will be requested for the interview. The candidate must demonstrate prior experience in cell culture and molecular biology, as well as hematology. Rigorous, organized and proactive, the candidate should show a strong interest/enthusiasm for science, a solid team spirit, and the ability to innovate and work independently.
Your Work Environment
The position is available at the Institute of Human Genetics within the 'Epigenome modifications and genomic instability in normal and malignant B cells' team. A 12-month fixed-term contract, renewable. The IHG is located on the Arnaud de Villeneuve campus, which is a participant in the 'Objectif Employeur Pro-Vélo' scheme.
Compensation and benefits
Compensation
from €2,521 gross per month, subject to adjustment based on professional experience in equivalent roles
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR9002-JERMOR-013 |
|---|---|
| Line of business | Life, Earth and Environmental Sciences |
| Job Type | Biological Techniques Engineer |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
Create your alert
Don't miss any opportunity to find the job that's right for you. Register for free and receive new vacancies directly in your mailbox.