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Reference : UMR9002-JERDEJ-001
Workplace : MONTPELLIER
Date of publication : Monday, July 27, 2020
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 October 2020
Proportion of work : Full time
Remuneration : Between 29000 and 36000 depending on experience
Desired level of education : PhD
Experience required : 1 to 4 years
Metastable epialleles are alleles that are variably expressed in genetically identical individuals. These epialleles are established during early development by epigenetic modifications in a process influenced by stress and the environment. The epiallele's state can subsequently be maintained throughout development and adult life. All known examples of epialleles involve the insertion of a transposable element, whose variable methylation among individuals correlates with local gene expression. However, the mechanisms underlying interindividual metastability are unknown. We have purified and established the proteome of one such transposable element and found that, in addition, it has the potential to contact multiple chromosomal regions, that we suspect alter such transposable element silencing capacity.
The researcher will explore this mechanism by using cutting-edge chromosome conformation methods, genetics and mouse models, chromatin proteomics and biochemistry.
a PhD in chromatin/genetics/epigenetics/genomics research
a proven track record of research activities
Knowledge in chromatin biochemistry and epigenomics approches (Hi-C, ChiP-seq, RNA-seq, etc...)
Experience with long DNA sequencing would be a plus.
A letter of recommendation from at least the PhD supervisor
Communicating in english
Our research group is located in the Institute of Human Genetics which provides a scientifically rich environment and opportunities for young scientists to thrive. IGH is equipped or has an easy access to cutting-edge sequencing/proteomics and imaging facilities.
Constraints and risks
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