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Portail > Offres > Offre UMR9002-GIACAV-008 - Poste de postdoc pour l'étude de l'organization en3D du génome durant la différenciation H/F

Postdoctoral position on 3D genome re-organization during differentiation H/F

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : jeudi 9 décembre 2021

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General information

Reference : UMR9002-GIACAV-008
Workplace : MONTPELLIER
Date of publication : Thursday, November 18, 2021
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 February 2022
Proportion of work : Full time
Remuneration : 3400 to 3800 € gross monthly salary
Desired level of education : 5-year university degree
Experience required : 5 to 10 years

Missions

One postdoctoral position is available for 12 months, from February 2022 to study the connection between chromatin architecture and transcription in the laboratory of Giacomo Cavalli.

Activities

Our lab has investigated the spatial organizational principles of the fly and the mammalian genome for two decades and has been a pioneer in assaying genome architecture using molecular biology approaches like HiC.
Using these approaches, we have shown that chromatin rewires during cellular differentiation concomitantly with transcriptional changes. The project will build upon these findings and utilize genetics, genome engineering, molecular biology and high-end-microscopy techniques to provide fundamental mechanistic insights into nuclear architecture and the relationship to transcription.

Skills

Candidates must have an outstanding CV, be highly motivated, self-driven and hardworking.
Extensive experience in molecular cloning, ES cell culture, neuronal differentiation, CRISPR, HiC, ChIP-seq, RNA-seq, FACS sorting, confocal microscopy as well as some experience with R, analysis of ChIP-seq and RNA-seq data will be essential. Experience with biochemistry techniques (IP, WB, co-IP) is a plus.

Work Context

The work will be performed in the laboratory of Giacomo Cavalli at the Institute of Human Genetics (IGH). IGH is a flagship institute for life science research and is located in the vibrant city of Montpellier, in the south of France. It offers state of the art equipment and facilities in a top-notch international environment.

Constraints and risks

No specific risks. This job requires strong commitment to basic science, team spirit, creativity and a rigorous approach to research.

Additional Information

Please apply by sending your CV, a statement of research interests, and if possible, arrange for two/three recommendation letters to be sent independently by the referees.
For more information, see our website:
https://www.igh.cnrs.fr/en/research/departments/genome-dynamics/21-chromatin-and-cell-biology

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